THE CO-AGONIST CONCEPT - IS THE NMDA-ASSOCIATED GLYCINE RECEPTOR SATURATED IN-VIVO

被引:71
作者
WOOD, PL
机构
关键词
GLYCINE; D-SERINE; NMDA; EXCITATORY AMINO ACIDS; CEREBELLUM; HIPPOCAMPUS;
D O I
10.1016/0024-3205(95)00288-H
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Our current knowledge of the structure and function of NMDA receptors is expanding at a rapid pace; however, advances regarding regulation of the supply of glutamate and its co-agonist, glycine, have been slower. While the anatomical sources and metabolic compartmentation of glutamate have been studied, limited efforts have been dedicated to defining the dynamics and compartmentation of the co-agonist, glycine. In fact, most investigators have made the assumption that glycine is freely available, via diffusion, for synaptic transmission at NMDA-type synaptic clefts. This assumption ignores the intricate inactivation mechanisms potentially involved in regulating synaptic levels of this amino acid and the recent descriptions of high levels of endogenous D-serine, another potential agonist of the NMDA-associated glycine receptor, in the brain. In this review, the relevance of these data and pharmacological experiments pertinent to the question of whether the NMDA-associated glycine receptor is saturated in vivo or not, is presented.
引用
收藏
页码:301 / 310
页数:10
相关论文
共 62 条
[1]   ULTRASTRUCTURAL LOCALIZATION OF D-AMINO-ACID OXIDASE IN MICROPEROXISOMES OF THE RAT NERVOUS-SYSTEM [J].
ARNOLD, G ;
LISCUM, L ;
HOLTZMAN, E .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1979, 27 (03) :735-745
[2]   D-CYCLOSERINE, A NOVEL COGNITIVE ENHANCER, IMPROVES SPATIAL MEMORY IN AGED RATS [J].
BAXTER, MG ;
LANTHORN, TH ;
FRICK, KM ;
GOLSKI, S ;
WAN, RQ ;
OLTON, DS .
NEUROBIOLOGY OF AGING, 1994, 15 (02) :207-213
[3]   PRESENCE OF THE N-METHYL-D-ASPARTATE-ASSOCIATED GLYCINE RECEPTOR AGONIST, D-SERINE, IN HUMAN TEMPORAL CORTEX - COMPARISON OF NORMAL, PARKINSON, AND ALZHEIMER TISSUES [J].
CHOUINARD, ML ;
GAITAN, D ;
WOOD, PL .
JOURNAL OF NEUROCHEMISTRY, 1993, 61 (04) :1561-1564
[4]   GLYCINE IS REQUIRED FOR NMDA RECEPTOR ACTIVATION - ELECTROPHYSIOLOGICAL EVIDENCE FROM INTACT RAT HIPPOCAMPUS [J].
DALKARA, T ;
ERDEMLI, G ;
BARUN, S ;
ONUR, R .
BRAIN RESEARCH, 1992, 576 (02) :197-202
[5]   AN [NA+ +K+]COUPLED L-GLUTAMATE TRANSPORTER PURIFIED FROM RAT-BRAIN IS LOCATED IN GLIAL-CELL PROCESSES [J].
DANBOLT, NC ;
STORMMATHISEN, J ;
KANNER, BI .
NEUROSCIENCE, 1992, 51 (02) :295-310
[6]   MODULATION OF GLUTAMATE RECEPTORS BY PHENCYCLIDINE AND GLYCINE IN THE RAT CEREBELLUM - CGMP INCREASE INVIVO [J].
DANYSZ, W ;
WROBLEWSKI, JT ;
BROOKER, G ;
COSTA, E .
BRAIN RESEARCH, 1989, 479 (02) :270-276
[7]   ACTIONS OF D-CYCLOSERINE AT THE N-METHYL-D-ASPARTATE-ASSOCIATED GLYCINE RECEPTOR-SITE INVIVO [J].
EMMETT, MR ;
MICK, SJ ;
CLER, JA ;
RAO, TS ;
IYENGAR, S ;
WOOD, PL .
NEUROPHARMACOLOGY, 1991, 30 (11) :1167-1171
[8]   D-CYCLOSERINE ATTENUATES SCOPOLAMINE-INDUCED LEARNING AND MEMORY DEFICITS IN RATS [J].
FISHKIN, RJ ;
INCE, ES ;
CARLEZON, WA ;
DUNN, RW .
BEHAVIORAL AND NEURAL BIOLOGY, 1993, 59 (02) :150-157
[9]   EFFECT ON MEMORY PROCESSING BY D-CYCLOSERINE, AN AGONIST OF THE NMDA GLYCINE RECEPTOR [J].
FLOOD, JF ;
MORLEY, JE ;
LANTHORN, TH .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 221 (2-3) :249-254
[10]  
GOODNOUGH DB, IN PRESS WOOD J CHRO