PHOTOCHEMICAL ONE-POT SYNTHESIS OF VINBLASTINE AND VINCRISTINE

被引：19

作者：

PENNANEN, S ^{[1
]}

HUHTIKANGAS, A ^{[1
]}

机构：

[1] UNIV KUOPIO,INST PHARMACEUT CHEM,SF-70211 KUOPIO,FINLAND

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 51卷 / 05期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01959.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The naturally occurring cytostatic dimer alkaloids vinblastine 1 and vincristine 2 were photochemically synthesized in slightly acidic aqueous solution from the monomer alkaloids catharan‐thine 3 and vindoline 4. Multi‐centre reactions should obviously be involved and some of the principal photochemistry‐associated phenomena here discussed are quite likely to be characteristic even to the biosynthetic reactions yielding vinblastine 1 and vincristine 2 in the cells of Catharanthus roseus. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：515 / 518

页数：4

共 18 条

[1]

ATTAURRAHMAN, 1979, Patent No. 155054

[2]

DEBRUYN A, 1980, B SOC CHIM BELG, V8, P629

[3]

DOUGLAS DE, 1976, ORGANIC MAGNET RES, V8, P413

[4] BIOTRANSFORMATION OF ANHYDROVINBLASTINE TO VINBLASTINE BY A CELL-FREE-EXTRACT OF CATHARANTHUS-ROSEUS CELL-SUSPENSION CULTURES [J].

ENDO, T ;

GOODBODY, A ;

VUKOVIC, J ;

MISAWA, M .

PHYTOCHEMISTRY, 1987, 26 (12) :3233-3234

[5] BIOSYNTHESIS OF THE INDOLE ALKALOIDS - CELL-FREE SYSTEMS FROM CATHARANTHUS-ROSEUS PLANTS [J].

KUTNEY, JP ;

CHOI, LSL ;

HONDA, T ;

LEWIS, NG ;

SATO, T ;

STUART, KL ;

WORTH, BR .

HELVETICA CHIMICA ACTA, 1982, 65 (07) :2088-2101

[6]

KUTNEY JP, 1988, HETEROCYCLES, V27, P1827

[7]

KUTNEY JP, 1988, HETEROCYCLES, V27, P1837

[8]

KUTNEY JP, 1988, HETEROCYCLES, V27, P1845

[9] IMMUNOANALYTICAL METHODS FOR SCREENING VINDOLINE FROM CATHARANTHUS-ROSEUS CELL-CULTURES [J].

LAPINJOKI, S ;

VERAJANKORVA, H ;

HEISKANEN, J ;

NISKANEN, M ;

HUHTIKANGAS, A ;

LOUNASMAA, M .

PLANTA MEDICA, 1987, 53 (06) :565-567

[10] NON-OXIDATIVE METHODOLOGY FOR THE SYNTHESIS OF VINBLASTINE AND VINCRISTINE MODELS [J].

MAGNUS, P ;

LADLOW, M ;

ELLIOTT, J ;

KIM, CS .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (08) :518-520

← 1 2 →