THE RELATIONSHIP BETWEEN SPLENOMEGALY AND ANTIBODY TO THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM IN 2 GROUPS OF WOMEN WITH HIGH AND LOW ENLARGED SPLEEN RATES IN MADANG, PAPUA-NEW-GUINEA

被引:3
作者
BRABIN, L
BURKOT, TR
BRABIN, BJ
CRANE, GG
FORSYTH, KP
ALPERS, MP
VANDERKAAY, HJ
机构
[1] WHO, SPECIAL PROGRAMME RES & TRAINING TROP DIS, CH-1211 GENEVA 27, SWITZERLAND
[2] UNIV LIVERPOOL, LIVERPOOL SCH TROP MED, DEPT TROP PAEDIAT & INT CHILD HLTH, LIVERPOOL L3 5QA, ENGLAND
[3] INST MED RES, MADANG, PAPUA N GUINEA
[4] CONCORD REPATRIAT GEN HOSP, SYDNEY, AUSTRALIA
[5] WALTER & ELIZA HALL INST MED RES, MELBOURNE, AUSTRALIA
[6] LEIDEN STATE UNIV, INST TROP MED, PARASITOL LAB, 2312 AV LEIDEN, NETHERLANDS
关键词
D O I
10.1016/0035-9203(90)90374-N
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The objective of this study was to determine the prevalence of antibodies recognizing the circumsporozoite (CS) protein of Plasmodium by an enzyme-linked immunosorbent assay, in 2 subpopulations of women with significantly different enlarged spleen rates but similar exposure to malaria, on the north coast of Papua New Guinea. Antibody levels of immunoglobulin G (IgG) antibody to CS protein in the high and low spleen rate groups were similar (56·2% and 55·1%) but there was a significant difference in IgM (29·6% and 16·7%). In neither group did antibodies increase with parity (age). In both groups a high level of either IgG or IgM antibody to CS protein was associated with a high spleen rate and women with hyper-reactive malarious splenomegaly were more likely to be positive for both. Lower parasite rates were associated only with increased IgM antibody titres. High levels of antibody to blood-stage parasites were also present in the high spleen rate group, suggesting that antibodies to the CS protein were not protective. It is considered that cell-mediated immunity may be deficient in women with persistent splenomegaly. © 1990 OUP Publishing Ltd.
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页码:40 / 45
页数:6
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