LOCALIZATION OF GENE FOR HUMAN SYNDECAN, AN INTEGRAL MEMBRANE PROTEOGLYCAN AND A MATRIX RECEPTOR, TO CHROMOSOME-2

被引：12

作者：

ALAKAPEE, M

NEVANLINNA, H

MALI, M

JALKANEN, M

SCHRODER, J

机构：

[1] UNIV HELSINKI,DEPT OBSTET & GYNECOL,SF-00100 HELSINKI 10,FINLAND

[2] UNIV TURKU,DEPT MED BIOCHEM,SF-20500 TURKU 50,FINLAND

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1990年 / 16卷 / 05期

关键词：

D O I：

10.1007/BF01233200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syndecan, a cell surface proteoglycan, is an integral membrane protein acting as a receptor for the extracellular matrix. For chromosomal localization of the human syndecan gene, a panel of mouse-human somatic cell hybrids was analyzed by Southern blotting using the cDNA probe for human syndecan. The hybrids were karyotyped at the time of DNA extraction. A band corresponding to the human syndecan gene in Southern blots was found only in a hybrid cell line containing human chromosome 2. This hybrid was subcloned and its subclones were analyzed by Southern blotting and karyotyped. Subclones carrying human chromosome 2 contained the syndecan gene, while subclones not carrying this chromosome did not. The human syndecan gene is thus assigned to chromosome 2. © 1990 Plenum Publishing Corporation.

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页码：501 / 505

页数：5

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