EXPRESSION OF CYTOKERATIN-8 IN HUMAN AORTIC SMOOTH-MUSCLE CELLS

被引:20
作者
GLUKHOVA, MA [1 ]
SHEKHONIN, BV [1 ]
KRUTH, H [1 ]
KOTELIANSKY, VE [1 ]
机构
[1] NHLBI,BETHESDA,MD 20892
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 04期
关键词
CYTODIFFERENTIATION; FETAL PHENOTYPE; LIPID ACCUMULATION;
D O I
10.1152/ajpheart.1991.261.4.72
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
An immunofluorescence method was used to study the expression of cytokeratin 8 in human aortic smooth muscle cells (SMCs) during prenatal development and in atherosclerotic plaques. Aortic SMCs from a 10-wk-old fetus contained cytokeratin 8 in additional to vimentin and a small amount of desmin, whereas, in the cells from a 25-wk-old fetus, cytokeratin 8 was not detected. Cytokeratin 8 was found in the SMCs from intimal thickenings, fatty streaks, and atherosclerotic fibrous plaques. Clusters of cytokeratin 8-positive cells were more abundant in rather advanced lesions (fibrous plaques) that contained at least some amount of lipid. Expression of cytokeratin 8 in the cells of human atherosclerotic lesions probably reflects general rearrangement of gene expression in the intimal cells.
引用
收藏
页码:72 / 77
页数:6
相关论文
共 25 条
[1]  
BADER BL, 1988, EUR J CELL BIOL, V47, P300
[2]   CYTOKERATIN EXPRESSION IN SMOOTH-MUSCLE AND SMOOTH-MUSCLE TUMORS [J].
BROWN, DC ;
THEAKER, JM ;
BANKS, PM ;
GATTER, KC ;
MASON, DY .
HISTOPATHOLOGY, 1987, 11 (05) :477-486
[3]   AORTIC SMOOTH-MUSCLE CELLS CONTAIN VIMENTIN INSTEAD OF DESMIN [J].
FRANK, ED ;
WARREN, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (05) :3020-3024
[4]   VASCULAR SMOOTH-MUSCLE CELLS DIFFER FROM OTHER SMOOTH-MUSCLE CELLS - PREDOMINANCE OF VIMENTIN FILAMENTS AND A SPECIFIC ALPHA-TYPE ACTIN [J].
GABBIANI, G ;
SCHMID, E ;
WINTER, S ;
CHAPONNIER, C ;
DECHASTONAY, C ;
VANDEKERCHKHOVE, J ;
WEBER, K ;
FRANKE, WW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (01) :298-302
[5]   EXPRESSION OF FIBRONECTIN VARIANTS IN VASCULAR AND VISCERAL SMOOTH-MUSCLE CELLS IN DEVELOPMENT [J].
GLUKHOVA, MA ;
FRID, MG ;
SHEKHONIN, BV ;
BALABANOV, YV ;
KOTELIANSKY, VE .
DEVELOPMENTAL BIOLOGY, 1990, 141 (01) :193-202
[6]  
GLUKHOVA MA, 1990, J BIOL CHEM, V265, P13042
[7]   MODULATION OF HUMAN AORTA SMOOTH-MUSCLE CELL PHENOTYPE - A STUDY OF MUSCLE-SPECIFIC VARIANTS OF VINCULIN, CALDESMON, AND ACTIN EXPRESSION [J].
GLUKHOVA, MA ;
KABAKOV, AE ;
FRID, MG ;
ORNATSKY, OI ;
BELKIN, AM ;
MUKHIN, DN ;
OREKHOV, AN ;
KOTELIANSKY, VE ;
SMIRNOV, VN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9542-9546
[8]  
GOWN AM, 1988, AM J PATHOL, V132, P223
[9]   HIGH-FREQUENCY OF CYTOKERATIN-PRODUCING SMOOTH-MUSCLE CELLS IN HUMAN ATHEROSCLEROTIC PLAQUES [J].
JAHN, L ;
FRANKE, WW .
DIFFERENTIATION, 1989, 40 (01) :55-62
[10]  
KAWAMOTO S, 1987, J BIOL CHEM, V262, P7282