EXPRESSION OF CYTOKERATIN-8 IN HUMAN AORTIC SMOOTH-MUSCLE CELLS

被引：20

作者：

GLUKHOVA, MA ^{[1
]}

SHEKHONIN, BV ^{[1
]}

KRUTH, H ^{[1
]}

KOTELIANSKY, VE ^{[1
]}

机构：

[1] NHLBI,BETHESDA,MD 20892

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 04期

关键词：

CYTODIFFERENTIATION; FETAL PHENOTYPE; LIPID ACCUMULATION;

D O I：

10.1152/ajpheart.1991.261.4.72

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

An immunofluorescence method was used to study the expression of cytokeratin 8 in human aortic smooth muscle cells (SMCs) during prenatal development and in atherosclerotic plaques. Aortic SMCs from a 10-wk-old fetus contained cytokeratin 8 in additional to vimentin and a small amount of desmin, whereas, in the cells from a 25-wk-old fetus, cytokeratin 8 was not detected. Cytokeratin 8 was found in the SMCs from intimal thickenings, fatty streaks, and atherosclerotic fibrous plaques. Clusters of cytokeratin 8-positive cells were more abundant in rather advanced lesions (fibrous plaques) that contained at least some amount of lipid. Expression of cytokeratin 8 in the cells of human atherosclerotic lesions probably reflects general rearrangement of gene expression in the intimal cells.

引用

页码：72 / 77

页数：6

共 25 条

[1]

BADER BL, 1988, EUR J CELL BIOL, V47, P300

[2] CYTOKERATIN EXPRESSION IN SMOOTH-MUSCLE AND SMOOTH-MUSCLE TUMORS [J].