THE PRES1 DOMAIN OF HEPATITIS-B VIRUS AND IGA CROSS-REACT IN THEIR BINDING TO THE HEPATOCYTE SURFACE

被引：38

作者：

PONTISSO, P

RUVOLETTO, MG

TIRIBELLI, C

GERLICH, WH

RUOL, A

ALBERTI, A

机构：

[1] UNIV PADUA,MED CLIN 2,IST MED CLIN,I-35100 PADUA,ITALY

[2] UNIV TRIESTE,DIPARTIMENTO BIOCHIM & BIOFIS,I-34127 TRIESTE,ITALY

[3] UNIV GIESSEN,INST MED VIROL,W-6300 GIESSEN,GERMANY

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-8-2041

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Using a solid-phase assay we have demonstrated specific competition between the preS1 sequence of hepatitis B virus and human IgA in their binding to isolated normal human liver plasma membranes, suggesting molecular mimicry. Monoclonal and polyclonal antibodies raised against virus and IgA epitopes were used to detect and map immunological cross-reactivity to the virus sequence involved in liver cell binding. These findings suggest the existence of a common receptor or of closely related receptors for the attachment of HBV and IgA to human liver cells.

引用

页码：2041 / 2045

页数：5

共 21 条

[1] AN ANTIBODY WHICH PRECIPITATES DANE PARTICLES IN ACUTE HEPATITIS TYPE-B - RELATION TO RECEPTOR-SITES WHICH BIND POLYMERIZED HUMAN-SERUM ALBUMIN ON VIRUS-PARTICLES [J].