VITISIN-A AND CIS-VITISIN-A, STRONGLY HEPATOTOXIC PLANT OLIGOSTILBENES FROM VITIS-COIGNETIAE (VITACEAE)

被引：36

作者：

OSHIMA, Y ^{[1
]}

KAMIJOU, A ^{[1
]}

MORITANI, H ^{[1
]}

NAMAO, K ^{[1
]}

OHIZUMI, Y ^{[1
]}

机构：

[1] TOHOKU UNIV, INST PHARMACEUT, AOBA KU, SENDAI, MIYAGI 980, JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 04期

关键词：

D O I：

10.1021/jo00056a016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The methanolic extract of one of the common Vitaceaeous plants, Vitis coignetiae, showed marked prevention against injuries of primary cultured rat liver cells induced by carbon tetrachloride and D-galactosamine. Activity-guided fractionation of the extract resulted in the isolation of not only an antihepatotoxic stilbene derivative, epsilon-viniferin, but also novel oligostilbenes, vitisin A and its stereoisomer cis-vitisin A as a mixture. The structures of the oligostilbenes have been determined on the basis of spectroscopic evidence, especially by 2D NMR methods such as HMBC spectra of degradative products. The mixture of vitisin A and cis-vitisin A was found to cause marked liver lesions in mice.

引用

页码：850 / 853

页数：4

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