AMINATION WITH N-BENZYLOXYCARBONYL-3-PHENYLOXAZIRIDINE AS A ROUTE TO SENSITIVE CHIRAL ALPHA-HYDRAZINO ACIDS - SYNTHESIS OF L-HYDRAZINO SERINE

被引：28

作者：

NIEDERER, DA ^{[1
]}

KAPRON, JT ^{[1
]}

VEDERAS, JC ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT CHEM,EDMONTON T6G 2G2,ALBERTA,CANADA

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)91814-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Cbz-3-phenyloxaziridine can be generated in a two step process. This is a new reagent for direct electrophilic N-amination of chiral alpha-amino acids and their derivatives which affords the corresponding hydrazino acids protected with a readily removable N-Cbz group. Application of this methodology to a facile synthesis of L-hydrazino serine, a potentially useful biological tool, is described

引用

页码：6859 / 6862

页数：4

共 24 条

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