THE EFFECT OF MENOPAUSAL STATUS AND SEQUENTIAL MESTRANOL AND NORETHISTERONE ON SERUM BIOCHEMICAL PROFILES

Serum biochemical profiles were compared in matched groups of premenopausal and postmenopausal women. Significantly higher concentrations of Na, urea, Ca, albumin and alkaline phosphatase were found in the postmenopausal group. In the postmenopausal group, following treatment with sequential mestranol and norethisterone, significant reductions were recorded in the concentrations of Na, urea, Ca, albumin, alkaline phosphatase and glucose and significant increases were recorded in the concentration of globulin and in body weight. Apparently, hemoconcentration may take place after the menopause and this effect may be modified by hormone treatment. No adverse effect on liver function was noted following the hormone treatment.