FREQUENIN - A NOVEL CALCIUM-BINDING PROTEIN THAT MODULATES SYNAPTIC EFFICACY IN THE DROSOPHILA NERVOUS-SYSTEM

被引:291
作者
PONGS, O
LINDEMEIER, J
ZHU, XR
THEIL, T
ENGELKAMP, D
KRAHJENTGENS, I
LAMBRECHT, HG
KOCH, KW
SCHWEMER, J
RIVOSECCHI, R
MALLART, A
GALCERAN, J
CANAL, I
BARBAS, JA
FERRUS, A
机构
[1] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, W-5170 JULICH 1, GERMANY
[2] RUHR UNIV BOCHUM, AG SEHPHYSIOL, W-4630 BOCHUM 1, GERMANY
[3] CNRS, NEUROBIOL CELLULAIRE & MOLEC LAB, F-91198 GIF SUR YVETTE, FRANCE
[4] CSIC, INST CAJAL, E-28002 MADRID, SPAIN
关键词
D O I
10.1016/0896-6273(93)90267-U
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The T(X;Y)V7 rearrangement in Drosophila has originally been recognized as a Shaker-like mutant because of its behavioral and electrophysiological phenotype. The gene whose expression is altered by the V7 rearrangement has been characterized. It encodes a novel Ca2+-binding protein named frequenin, which is related to recoverin and visinin. In vitro, the frequenin protein functions like recoverin as a Ca2+-sensitive guanylyl cyclase activator. Anti-frequenin antibodies stain the central and peripheral nervous system in Drosophila embryos and in larval and adult tissue sections. Frequenin appears to be particularly enriched in synapses, such as the motor nerve endings at neuromuscular junctions. Neuromuscular junctions of transgenic flies, which overexpress frequenin upon heat shock, exhibit an extraordinarily enhanced, frequency-dependent facilitation of neurotransmitter release, with properties identical to those observed in V7 junctions. We propose that frequenin represents a new element for the Ca2+-dependent modulation of synaptic efficacy.
引用
收藏
页码:15 / 28
页数:14
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