MOLECULAR-CONFORMATIONS OF MET-ENKEPHALIN - COMPARISON OF ZWITTERIONIC AND CATIONIC FORMS

被引：49

作者：

JONES, CR

GARSKY, V

GIBBONS, WA

机构：

[1] UNIV WISCONSIN, COLL AGR & LIFE SCI, DEPT BIOCHEM, MADISON, WI 53706 USA

[2] UNIV WISCONSIN, COLL AGR & LIFE SCI, INST ENZYME, MADISON, WI 53706 USA

[3] WYETH LABS INC, RADNOR, PA 19087 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1977年 / 76卷 / 03期

关键词：

D O I：

10.1016/0006-291X(77)91546-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apparent discrepancies in published assignments of the PMR spectrum of Met5-enkephalin were due to the existence of 2 forms, cationic and zwitterionic. The PMR parameters of these 2 forms indicated different secondary conformations. The PMR parameters of the zwitterionic form were indicative of a 2-5 .beta.-I turn but no secondary conformation could be suggested for the cationic form with the present data.

引用

页码：619 / 625

页数：7

共 12 条

[1] BELLUZI JD, 1976, NATURE, V260, P624
[2] 360 MHZ PROTON NMR-SPECTRA OF ACTIVE AND INACTIVE DERIVATIVES OF METHIONINE-ENKEPHALIN - ASSIGNMENTS, DERIVED PARAMETERS, CONFORMATIONAL IMPLICATIONS
BLEICH, HE
DAY, AR
FREER, RJ
GLASEL, JA
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 74 (02) : 592 - 598
[3] PRELIMINARY-ANALYSIS OF H-1 AND C-13 SPECTRAL AND RELAXATION BEHAVIOR IN METHIONINE-ENKEPHALIN
BLEICH, HE
CUTNELL, JD
DAY, AR
FREER, RJ
GLASEL, JA
MCKELVY, JF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (08) : 2589 - 2593
[4] BIOSYNTHETIC ORIGIN AND RECEPTOR CONFORMATION OF METHIONINE ENKEPHALIN
BRADBURY, AF
SMYTH, DG
SNELL, CR
[J]. NATURE, 1976, 260 (5547) : 165 - 166
[5] C FRAGMENT OF LIPOTROPIN HAS A HIGH AFFINITY FOR BRAIN OPIATE RECEPTORS
BRADBURY, AF
SMYTH, DG
SNELL, CR
BIRDSALL, NJM
HULME, EC
[J]. NATURE, 1976, 260 (5554) : 793 - 795
[6] INTRAMOLECULAR MOTION IN PEPTIDES DETERMINED BY C-13 NMR - SPIN-LATTICE RELAXATION TIME-STUDY ON MSH-RELEASE-INHIBITING FACTOR
DESLAURIERS, R
WALTER, R
SMITH, ICP
[J]. FEBS LETTERS, 1973, 37 (01): : 27 - 32
[7] PREFERENTIAL CONFORMATION OF ENDOGENOUS OPIATE-LIKE PENTAPEPTIDE MET-ENKEPHALIN IN DMSO-D6 SOLUTION DETERMINED BY HIGH-FIELD H-1 NMR
GARBAYJAUREGUIBERRY, C
ROQUES, BP
OBERLIN, R
ANTEUNIS, M
LALA, AK
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 71 (02) : 558 - 565
[8] STRUCTURAL AND CONFORMATIONAL RELATIONSHIPS BETWEEN ENKEPHALINS AND OPIATES
HORN, AS
RODGERS, JR
[J]. NATURE, 1976, 260 (5554) : 795 - 797
[9] IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY
HUGHES, J
SMITH, TW
KOSTERLITZ, HW
FOTHERGILL, LA
MORGAN, BA
MORRIS, HR
[J]. NATURE, 1975, 258 (5536) : 577 - 579
[10] PROTON MAGNETIC-RESONANCE STUDIES OF CONFORMATION AND FLEXIBILITY OF ENKEPHALIN PEPTIDES
JONES, CR
GIBBONS, WA
GARSKY, V
[J]. NATURE, 1976, 262 (5571) : 779 - 782

← 1 2 →