SYNTHESIS AND EVALUATION OF THE ANTI-OVULATORY ACTIVITY OF A VARIETY OF MELATONIN ANALOGS

被引:65
作者
FLAUGH, ME
CROWELL, TA
CLEMENS, JA
SAWYER, BD
机构
[1] The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana
关键词
D O I
10.1021/jm00187a015
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position. © 1979, American Chemical Society. All rights reserved.
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页码:63 / 69
页数:7
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