INTESTINAL LACTASE STATUS OF ADULTS IN PAPUA-NEW-GUINEA

Fifty hospital patients in Port Moresby (mean age 30 yr) without evidence of malnutrition or gastro-intestinal disease, who came from many parts of Papua New Guinea (P.N.G.), were given 50g lactose orally after an overnight fast. In 49 blood glucose rise was <1·1 mmol 1-1, indicating hypolactasia. Thirty-three gave a clear history of symptoms, usually diarrhoea, after lactose. Adult hypolactasia approaches 100% in P.N.G. There is no indication that the genetic structure of any part of the population of P.N.G. with regard to lactase has been influenced by genetic drift from peoples with persistence of lactase into adult life (PL). © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.