DYNAMICS OF ESTRADIOL AND TESTOSTERONE UPTAKE IN THE BRAIN OF ADULT MALE-RATS

被引：5

作者：

HENDERSON, SB ^{[1
]}

CIACCIO, LA ^{[1
]}

KINCL, FA ^{[1
]}

机构：

[1] CUNY COLL STATEN ISL,DEPT BIOL,STATEN ISL,NY 10301

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1979年 / 11卷 / 5-6期

关键词：

D O I：

10.1016/0022-4731(79)90356-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[3H]-Estradiol (1.28 μmol) and [14C]-testosterone (243 μmol) were given in an i.v. bolus and the concentration of both steroids in the central nervous system at different times was studied. Uptake and retention of phenolic steroids in the pituitary and the hypothalamus was higher than found in peripheral plasma indicating preferential concentration which persisted for more than 2 h. In contrast the uptake of testosterone and dihydrotestosterone was lower than could be expected from concentration in peripheral plasma and these compounds disappeared within 0.5 h after the pulse. © 1979.

引用

页码：1601 / 1607

页数：7

共 30 条

[1] NUCLEAR RECEPTOR ESTROGEN COMPLEX - ACCUMULATION, RETENTION AND LOCALIZATION IN HYPOTHALAMUS AND PITUITARY [J].