REGULATION OF ALDOSTERONE BIOSYNTHESIS - A CONTINUAL CHALLENGE

被引：5

作者：

MULLER, J

LAUBER, M

机构：

[1] Steroid Laboratory, Department of Medicine, University Hospital, Zürich

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 03期

关键词：

SODIUM INTAKE; POTASSIUM INTAKE; RAT; CYTOCHROME P-450-BETA;

D O I：

10.1093/ajh/4.3.280

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aldosterone secretion by the zona glomerulosa of the adrenal cortex is directly influenced by a large, growing number of different physiologic agents. Their action includes: 1) acute stimulation or inhibition of early biosynethetic steps; 2) long-term activation or suppression of late biosynthetic steps; and 3) induction of growth or atrophy of zona glomerulosa cells. In rats, adaptation of late steps of aldosterone biosynthesis to sodium and potassium intake is mediated by the induction or repression of a second form of cytochrome P-450(11-beta), which differs from the main form of the enzyme by a lower molecular weight and a greater range of catalytic properties.

引用

页码：280 / 282

页数：3

共 14 条

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