THE MALE ANTIFERTILITY ACTIVITY OF 6-CHLORO-6-DEOXYGLUCOSE

被引：8

作者：

JONES, AR

DOBBIE, MS

机构：

[1] Department of Biochemistry, The University of Sydney, Sydney

来源：

CONTRACEPTION | 1991年 / 44卷 / 06期

关键词：

D O I：

10.1016/0010-7824(91)90084-S

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

6-Chloro-6-deoxy[U-C-14]glucose is not metabolised by mature boar spermatozoa nor has it any specific inhibitory action on their metabolic activity in vitro. The compound is metabolised by the male rat and the identification of two urinary metabolites as alpha-chlorohydrin and 3-chlorolactate confirmed that (S)-3-chlorolactaldehyde is produced by this species in vivo. A tissue distribution study revealed that radioactivity from 6-chloro-6-deoxy[U-C-14]glucose was more concentrated in rat caudal spermatozoa than in any other of the major tissues.

引用

页码：649 / 655

页数：7

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