METABOLIC CHANNELING AND CONTROL OF THE FLUX

被引：88

作者：

KHOLODENKO, BN

WESTERHOFF, HV

机构：

[1] UNIV AMSTERDAM, EC SLATER INST, PLANTAGE MUIDERGRACHT 12, AMSTERDAM, NETHERLANDS

[2] NETHERLANDS CANC INST, DIV MOLEC BIOL, 1066 CX AMSTERDAM, NETHERLANDS

来源：

FEBS LETTERS | 1993年 / 320卷 / 01期

关键词：

METABOLIC CONTROL THEORY; CONTROL COEFFICIENT; DIRECT TRANSFER; ENZYME ENZYME INTERACTION AND KINETICS;

D O I：

10.1016/0014-5793(93)81660-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic control theory is extended to include channelled metabolism in general. A simple relationship between the flux control by the enzymes and the degree of metabolite channelling is derived. This relationship suggests experiments in which modulation of gene expression allows one to quantify channelling.

引用

页码：71 / 74

页数：4

共 16 条

[1] Cornish-Bowden A, 1976, PRINCIPLES ENZYME KI
[2] HEINRICH R, 1977, PROG BIOPHYS MOL BIO, V32, P1
[3] THE USE OF LAC-TYPE PROMOTERS IN CONTROL ANALYSIS
JENSEN, PR
WESTERHOFF, HV
MICHELSEN, O
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 211 (1-2): : 181 - 191
[4] KACSER H, 1973, RATE CONTROL BIOL PR, P65
[5] KELL DB, 1990, UCLA SYM BI, V133, P273
[6] CHANNELED PATHWAYS CAN BE MORE SENSITIVE TO SPECIFIC REGULATORY SIGNALS
KHOLODENKO, BN
DEMIN, OV
WESTERHOFF, HV
[J]. FEBS LETTERS, 1993, 320 (01): : 75 - 78
[7] CONTROL OF THE METABOLIC FLUX IN A SYSTEM WITH HIGH ENZYME CONCENTRATIONS AND MOIETY-CONSERVED CYCLES - THE SUM OF THE FLUX CONTROL COEFFICIENTS CAN DROP SIGNIFICANTLY BELOW UNITY
KHOLODENKO, BN
LYUBAREV, AE
KURGANOV, BI
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 210 (01): : 147 - 153
[8] KHOLODENKO BN, 1993, IN PRESS BIOKHIMIA, V58
[9] KHOLODENKO BN, 1993, MODERN TRENDS BIOTHE
[10] KHOLODENKO BN, 1991, MODERN THEORY METABO

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