SYNTHESIS OF 5-DEOXY-5-FLUORO-NETILMICIN AND 5-DEOXY-5,5-DIFLUORO-NETILMICIN

被引：7

作者：

UMEMURA, E ^{[1
]}

TSUCHIYA, T ^{[1
]}

KOYAMA, Y ^{[1
]}

UMEZAWA, S ^{[1
]}

机构：

[1] INST BIOORGAN CHEM,1614 IDA,NAKAHARA KU,KAWASAKI 211,JAPAN

来源：

CARBOHYDRATE RESEARCH | 1993年 / 238卷

关键词：

D O I：

10.1016/0008-6215(93)87010-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5-Deoxy-5-fluoro- (9) and 5-deoxy-5,5-difluoro-netilmicin (27) have been prepared from the corresponding 5-epi and 5-oxo derivatives of netilmicin by treatment with DAST. Structures of the fluorinated by-products (10, 11, and 12) obtained in one of the synthesis of 9 were determined. 5-Epinetilmicin (13) and 5-epi-6'-N-methylnetilmicin (21) have also been prepared.

引用

页码：147 / 162

页数：16

共 6 条

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