The Effects of Arterial Blood Pressure on the Regional Cerebral Blood Volume by X-Ray Fluorescence

被引：83

作者：

Grubb, Robert L., Jr. ^{[1
]}

Phelps, Michael E. ^{[2
]}

Raichle, Marcus E. ^{[3
]}

Ter-Pogossian, Michel M. ^{[2
]}

机构：

[1] Washington Univ, Sch Med, Div Neurosurg, 510 South Kingshighway, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Div Radiat Phys, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Div Neurol, St Louis, MO 63110 USA

来源：

STROKE | 1973年 / 4卷 / 03期

基金：

美国国家卫生研究院;

关键词：

autoregulation; contrast agents;

D O I：

10.1161/01.STR.4.3.390

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral blood flow (CBF) remains constant over a wide range of arterial blood pressure. This is thought to be accomplished by changes in the diameter, and therefore the volume, of the cerebral resistance vessels. To test this hypothesis, regional cerebral blood volume (rCBV) was measured in vivo in Rhesus monkeys over a range of mean arterial blood pressures (MABP) of 35 to 200 torr. Multiple measurements were made in each animal by the method of stimulated x-ray fluorescence. A significant linear relationship of rCBV = 6.26 (+/- 0.47 SD) - 0.015 (+/- 0.004 SD) MABP was found. For each one torr change in the MABP, there is a change in rCBV of 0.015 cc/100 gm of brain tissue over a range of MABP of 35 to 200 torr. An additional observation of this investigation was that autoregulation of the cerebral blood flow (CBF) is perturbed for a period lasting up to 15 minutes after the intravenous injection of Renografin-76(R)..

引用

页码：390 / 399

页数：10

共 24 条

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