MEIOTIC DRIVE ON ABERRANT CHROMOSOME-1 IN THE MOUSE IS DETERMINED BY A LINKED DISTORTER

被引：21

作者：

AGULNIK, SI ^{[1
]}

SABANTSEV, ID ^{[1
]}

ORLOVA, GV ^{[1
]}

RUVINSKY, AO ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,INST CYTOL & GENET,NOVOSIBIRSK 630090,RUSSIA

来源：

GENETICAL RESEARCH | 1993年 / 61卷 / 02期

关键词：

D O I：

10.1017/S0016672300031189

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An aberrant chromosome 1 carrying an inverted fragment with two amplified DNA regions was isolated from wild populations of Mus musculus. Meiotic drive favouring the aberrant chromosome was demonstrated for heterozygous females. Its cause was preferential passage of aberrant chromosome 1 to the oocyte. Genetic analysis allowed us to identify a two-component system conditioning deviation from equal segregation of the homologues. The system consists of a postulated distorter and responder. The distorter is located on chromosome 1 distally to the responder, between the ln and Pep-3 genes, and it acts on the responder when in trans position. Polymorphism of the distorters was manifested as variation in their effect on meiotic drive level in the laboratory strain and mice from wild populations.

引用

页码：91 / 96

页数：6

共 15 条

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