CALCIUM PERMEABILITY OF THE N-METHYL-D-ASPARTATE RECEPTOR-CHANNEL IN HIPPOCAMPAL-NEURONS IN CULTURE

被引：133

作者：

JAHR, CE ^{[1
]}

STEVENS, CF ^{[1
]}

机构：

[1] SALK INST BIOL STUDIES, SAN DIEGO, CA 92138 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 24期

关键词：

GLUTAMATE RECEPTORS; SYNAPSE; SINGLE CHANNEL; ION PERMEATION;

D O I：

10.1073/pnas.90.24.11573

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have developed a quantitative description for calcium permeability of the N-methyl-D-aspartate receptor channel to permit predictions of the reversal potential and calcium influx at different voltages for different extracellular calcium concentrations. Increasing the external calcium concentration markedly shifted the reversal potential to positive values and simultaneously decreased the single-channel conductance at potentials negative to the reversal potential. Very simple quantitative descriptions of calcium permeation and channel block by calcium ions accurately characterize our data and permit the prediction of reversal potentials and magnitudes of calcium influx for a wide range of conditions.

引用

页码：11573 / 11577

页数：5

共 33 条

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