H-1-NMR THERMODYNAMICAL ANALYSIS OF THE INTERACTIONS OF PROFLAVINE WITH SELF-COMPLEMENTARY DEOXYTETRANUCLEOTIDES OF DIFFERENT BASE SEQUENCE

被引:18
作者
DAVIES, DB [1 ]
DJIMANT, LN [1 ]
VESELKOV, AN [1 ]
机构
[1] SEVASTOPOL INSTRUMENT DEV INST,DEPT PHYS,SEVASTOPOL 335053,UKRAINE
来源
NUCLEOSIDES & NUCLEOTIDES | 1994年 / 13卷 / 1-3期
关键词
D O I
10.1080/15257779408013270
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Enthalpies and entropies of complex formation (1:1, 2:1, 1:2, and 2:2 complexes) between proflavine and tetranucleotides of different base sequence have been determined by 500 MHz proton NMR chemical shifts, enabling the contributions to be differentiated for the formation of different types of complexes in solution. Comparison of the calculated thermodynamical parameters has lead to an understanding of the nature of the intermolecular interactions responsible for the formation of dye complexes with the different tetranucleotides.
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收藏
页码:657 / 671
页数:15
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