VASCULAR ENDOTHELIAL GROWTH-FACTOR CAUSES ENDOTHELIAL PROLIFERATION AFTER VASCULAR INJURY

被引：30

作者：

BURKE, PA ^{[1
]}

LEHMANNBRUINSMA, K ^{[1
]}

POWELL, JS ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,DEPT MED,DAVIS,CA 95616

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 207卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factor was infused into rat carotid arteries for 3 minutes immediately after endothelial denudation by balloon injury. Endothelial proliferation was determined by immunohistochemical labelling of proliferating cell nuclear antigen using Hautchen preparations. The proliferation index, or number of proliferating cells/total cells, measured at 25.5 or 30 hours was markedly increased after infusion of vascular endothelial growth factor. In addition, the total number of proliferating cells increased with increasing doses up to 100 mu g total dose per infusion. These data indicate that infusion of vascular endothelial growth factor increases endothelial cell proliferation after mechanical denudation injury of the vascular wall. (C) 1995 Academic Press, Inc.

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页码：348 / 354

页数：7

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