ENDOGENOUS VERSUS TOXIN-INDUCED DIABETES IN RATS - A MECHANICAL COMPARISON OF 2 SKIN WOUND-HEALING MODELS

被引:32
作者
GREENWALD, DP
SHUMWAY, S
ZACHARY, LS
LABARBERA, M
ALBEAR, P
TEMANER, M
GOTTLIEB, LJ
机构
[1] UNIV CHICAGO, DEPT SURG, PLAST & RECONSTRUCT SURG SECT, CHICAGO, IL 60637 USA
[2] UNIV CHICAGO, DEPT ANAT & ORGANISMAL BIOL, CHICAGO, IL 60637 USA
关键词
D O I
10.1097/00006534-199305000-00018
中图分类号
R61 [外科手术学];
学科分类号
摘要
This study was designed to compare skin wound healing in three groups of Wistar rats: normal, genetically diabetic, and streptozotocin-induced diabetic. All diabetic animals received daily insulin. Full-thickness midline dorsal skin wounds were analyzed biomechanically for strength, toughness, and elasticity (Young's modulus) at 1 and 3 weeks after wounding. Wounds from normal controls were the strongest, toughest, and least compliant. Genetically diabetic rat wounds were the weakest and had the lowest elastic modulus. Wounds from the streptozotocin-induced rats were intermediate for all parameters measured (ANOVA, p = 0.001). Toxin-induced diabetes is less detrimental to skin wound healing than diabetes of endogenous origin. Whether this is due to basic differences in the models or to differences in duration of diabetes is unknown.
引用
收藏
页码:1087 / 1093
页数:7
相关论文
共 38 条
[1]   The treatment of diabetes [J].
Allen, FM .
BOSTON MEDICAL AND SURGICAL JOURNAL, 1915, 172 :241-247
[2]  
ANDREASSEN TT, 1987, ACTA CHIR SCAND, V153, P405
[3]   BIOMECHANICAL CHANGES IN CONNECTIVE TISSUES INDUCED BY EXPERIMENTAL DIABETES [J].
ANDREASSEN, TT ;
SEYERHANSEN, K ;
OXLUND, H .
ACTA ENDOCRINOLOGICA, 1981, 98 (03) :432-436
[4]   RENAL CALCIUM AND MAGNESIUM HANDLING IN EXPERIMENTAL DIABETES-MELLITUS IN THE RAT [J].
ANWANA, AB ;
GARLAND, HO .
ACTA ENDOCRINOLOGICA, 1990, 122 (04) :479-486
[5]  
BRENNAN M, 1989, J BIOL CHEM, V264, P29
[6]   STUDIES ON THE MECHANISM OF BILE SALT-INDEPENDENT BILE-FLOW IMPAIRMENT IN STREPTOZOTOCIN-INDUCED HEPATOTOXICITY [J].
CARNOVALE, CE ;
ROMA, MG ;
MONTI, JA ;
GARAY, EAR .
TOXICOLOGY, 1991, 68 (03) :207-215
[7]   5-YEAR PROSPECTIVE STUDY OF 23,649 SURGICAL WOUNDS [J].
CRUSE, PJE ;
FOORD, R .
ARCHIVES OF SURGERY, 1973, 107 (02) :206-210
[8]  
EAGLETON WP, 1904, AM MED, V4, P898
[9]  
GOODSON WH, 1979, SURG GYNECOL OBSTET, V149, P600
[10]   STUDIES OF WOUND-HEALING IN EXPERIMENTAL DIABETES-MELLITUS [J].
GOODSON, WH ;
HUNT, TK .
JOURNAL OF SURGICAL RESEARCH, 1977, 22 (03) :221-227