PHARMACEUTICAL PROSPECTING AND THE POTENTIAL FOR PHARMACEUTICAL CROPS, NATURAL PRODUCT DRUG DISCOVERY AND DEVELOPMENT AT THE UNITED-STATES NATIONAL-CANCER-INSTITUTE

被引：7

作者：

CRAGG, GM

BOYD, MR

GREVER, MR

SCHEPARTZ, S

机构：

来源：

ANNALS OF THE MISSOURI BOTANICAL GARDEN | 1995年 / 82卷 / 01期

关键词：

D O I：

10.2307/2399979

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemically-complex natural product drugs are not readily synthesized, and large-scale production for clinical and commercial development often involves isolation from the natural source. The rapidly escalating demand for taxol, originally isolated from the bark of Taxus brevifolia, has emphasized the need for alternative sources to the wild plant, and the National Cancer Institute (NCI) has developed policies for exploring such sources at the early stages of preclinical development of potential new drugs. The potential for pharmaceutical crop development in the case of several possible anti-AIDS agents will be discussed.

引用

页码：47 / 53

页数：7

共 27 条

[1]

Boyd M.K., 1989, CANCER PRINCIPLES PR, V3, P1

[2]

BOYD MR, 1988, AIDS ETIOLOGY DIAGNO, P305

[3]

CHANG HM, 1986, PHARM APPLICATIONS C, V1

[4]

COX PA, 1990, EC MED PLANT RES, V4, P123

[5]

CRAGG GM, 1994, MONOG SYST BOTAN, V48, P221

[6] THE TAXOL SUPPLY CRISIS - NEW NCI POLICIES FOR HANDLING THE LARGE-SCALE PRODUCTION OF NOVEL NATURAL PRODUCT ANTICANCER AND ANTI-HIV AGENTS [J].

CRAGG, GM ;

SCHEPARTZ, SA ;

SUFFNESS, M ;

GREVER, MR .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (10) :1657-1668

[7]

CRAGG GM, 1993, INT CROP SCI, V1, P465

[8] HIV INHIBITORY NATURAL-PRODUCTS .11. STRUCTURE, ABSOLUTE STEREOCHEMISTRY, AND SYNTHESIS OF CONOCURVONE, A POTENT, NOVEL HIV-INHIBITORY NAPHTHOQUINONE TRIMER FROM A CONOSPERMUM SP [J].

DECOSTERD, LA ;

PARSONS, IC ;

GUSTAFSON, KR ;

CARDELLINA, JH ;

MCMAHON, JB ;

CRAGG, GM ;

MURATA, Y ;

PANNELL, LK ;

STEINER, JR ;

CLARDY, J ;

BOYD, MR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (15) :6673-6679

[9] A HIGHLY EFFICIENT, PRACTICAL APPROACH TO NATURAL TAXOL [J].

DENIS, JN ;

GREENE, AE ;

GUENARD, D ;

GUERITTEVOEGELEIN, F ;

MANGATAL, L ;

POTIER, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (17) :5917-5919

[10] COST OF INNOVATION IN THE PHARMACEUTICAL-INDUSTRY [J].

DIMASI, JA ;

HANSEN, RW ;

GRABOWSKI, HG ;

LASAGNA, L .

JOURNAL OF HEALTH ECONOMICS, 1991, 10 (02) :107-142

← 1 2 3 →