MICROENCAPSULATION OF BITOLTEROL FOR CONTROLLED RELEASE AND ITS EFFECT ON BRONCHODILATOR AND HEART-RATE ACTIVITIES IN DOGS

被引：27

作者：

JOHN, PM

MINATOYA, H

ROSENBERG, FJ

机构：

[1] Sterling- Winthrop Research Institute, Rensselaer, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 04期

关键词：

Bitolterol—microencapsulation for controlled release; effects on bronchodilator and heart rate activities; dogs; Dosage forms—controlled‐release bitolterol formulations prepared by microencapsulation; Microencapsulation—bitolterol; controlled‐release characteristics assessed;

D O I：

10.1002/jps.2600680422

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Spheronized cores produced by extrusion and marumerization were microencapsulated with ethylcellulose by organic phase separation to produce beads exhibiting controlled‐release characteristics. In vitro dissolution studies indicated that the drug was released as a first‐order model and that the release rates were proportional to the amount of film on the bead. The bronchodilator activity in the anesthetized dog and the heart rate effect in the unanesthetized trained dog were evaluated. Microencapsulated beads were prepared which produced controlled release as assayed by bronchodilation. The heart rate increases induced by the controlled‐release formulations were gradual in onset, and the total increase in heart rate over a 6‐hr period was less than that associated with the plain drug powder. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：475 / 481

页数：7

共 24 条

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