THYROID-HORMONES UP-REGULATE CA-CHANNELS IN CULTURED SKELETAL-MUSCLE OF THE RAT

被引：12

作者：

BRODIE, C

SAMPSON, SR

机构：

[1] Health Sciences Research Center, Department of Life Sciences, Bar-Ilan University, Ramat-Gan

来源：

NEUROSCIENCE LETTERS | 1990年 / 117卷 / 03期

关键词：

Ca[!sup]2+[!/sup]-channel; Muscle culture; Thyroid hormone; Triiodothyronine;

D O I：

10.1016/0304-3940(90)90685-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of thyroid hormones (TH) were examined on the expression of slow Ca2+-channels in cultures of rat skeletal muscle. Myotubes were treated with TH at age 5-7 days in vitro, and measurements of specific binding of the dihydropyridine Ca-channel antagonist [3H]PN200-110 were made beginning 12 h later. TH caused a dose-related increase in PN200-110 binding sites with a lower affinity for the ligand than in control cells. The effect was blocked by simultaneous treatment with cycloheximide or actinomycin-D. The results indicate that TH increase gene expression of slow Ca2+-channels of skeletal muscle. © 1990.

引用

页码：325 / 330

页数：6

共 24 条

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