ELECTROCHEMICAL STUDIES OF CATIONIC DRUG INCLUSION COMPLEXES WITH ALPHA-CYCLODEXTRINS AND BETA-CYCLODEXTRINS

Drug membrane selective electrodes have been constructed for the cationic drug propranolol hydrochloride, diphenhydramine hydrochloride, diphenylpyraline hydrochloride and also chlorcyclizine hydrochloride. The characteristics of these drug selective electrodes have been evaluated and the electrodes used to measure equilibrium constants of the inclusion compounds involving the drugs with both alpha- and beta-cyclodextrins. The enthalpies and entropies associated with the formation of the inclusion complexes have also been estimated from the temperature dependence of the equilibrium constants.