DETERMINATION OF LIMITING IONIC MOBILITIES AND DISSOCIATION-CONSTANTS OF SOME LOCAL-ANESTHETICS

被引：16

作者：

POLASEK, M

GAS, B

HIROKAWA, T

VACIK, J

机构：

[1] CHARLES UNIV, FAC SCI, DEPT PHYS & MACROMOLEC CHEM, ALBERTOV 2030, CS-12840 PRAGUE 2, CZECHOSLOVAKIA

[2] HIROSHIMA UNIV, FAC ENGN, HIROSHIMA 724, JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 596卷 / 02期

关键词：

D O I：

10.1016/0021-9673(92)85015-L

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The limiting ionic mobilities and thermodynamic acid dissociation constants were calculated from isotachophoretic experiments for the local anaesthetics procaine, tetracaine, lidocaine, trimecaine, bupivacaine, cinchocaine, diperodone, diocaine, cocaine, psicaine-neu, tropacocaine, amylocaine, beta-eucaine and leucinocaine. The pH values at which the local anaesthetics with very similar limiting ionic mobilities can be isotachophoretically separated were determined from simulated mobility curves. The measuring apparatus employed a high-frequency contactless conductivity detector.

引用

页码：265 / 270

页数：6

共 19 条

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[2]

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[3]

CHMELA Z, 1987, THESIS PALACKY U OLO

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