ANTIMICROBIAL AGENTS FROM HETEROTHECA INULOIDES

被引：43

作者：

KUBO, I ^{[1
]}

MUROI, H ^{[1
]}

KUBO, A ^{[1
]}

CHAUDHURI, SK ^{[1
]}

SANCHEZ, Y ^{[1
]}

OGURA, T ^{[1
]}

机构：

[1] UNIV AUTONOMA GUADALAJARE,DEPT QUIM,GUADALAJARA,MEXICO

来源：

PLANTA MEDICA | 1994年 / 60卷 / 03期

关键词：

HETEROTHECA INULOIDES; ASTERACEAE; ANTIMICROBIAL ACTIVITY; BACTERICIDAL ACTIVITY; SESQUITERPENOIDS; 7-HYDROXY-3,4-DIHYDROCADALIN;

D O I：

10.1055/s-2006-959462

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

By bioassay directed fractionation, four sesquiterpenoids 1-4 were isolated as antimicrobial agents from the dried flowers of Heterotheca inuloides, a Mexican medicinal plant locally known as ''arnica''. 7-Hydroxy-3,4-dihydrocadalin (3) and 7-hydroxycadalin (4) exhibited potent antibacterial activity against Gram-positive bacteria with minimum inhibitory concentrations (MICs) ranging from 6.25 to 12.5 mu g/ml. Notably, 7-hydroxy-3,4-dihydrocadalin showed bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum bactericidal concentration (MBC) of 12.5 mu g/ml.

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页码：218 / 221

页数：4

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