HERPES-SIMPLEX GENES - THE BLUEPRINT OF A SUCCESSFUL HUMAN PATHOGEN

被引：109

作者：

WARD, PL

ROIZMAN, B

机构：

[1] Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, IL 60637

来源：

TRENDS IN GENETICS | 1994年 / 10卷 / 08期

关键词：

D O I：

10.1016/0168-9525(90)90009-U

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Herpes simplex virus genome encodes 75 proteins. Of these, only 37 are required for growth of the virus in culture. These essential genes encode functions related to entry of virus into cells, regulation of gene expression and replication and packaging of viral DNA info virions. The genes that are not essential for replication in culture play a key role in multiplication of the virus and its transfer from cell to cell, in complementing cellular functions lost as a consequence of viral replication, in fine-tuning viral gene expression find in overcoming the host's response to infection. No virally encoded functions are required for establishment of the latent state, but a full complement of viral genes is essential for efficient reactivation of the virus from the latent state.

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页码：267 / 274

页数：8

相关论文

共 35 条

[1] THE HERPES-SIMPLEX VIRUS UL37-PROTEIN IS PHOSPHORYLATED IN INFECTED-CELLS [J].

ALBRIGHT, AG ;

JENKINS, FJ .

JOURNAL OF VIROLOGY, 1993, 67 (08) :4842-4847

[2] THE UL11 GENE OF HERPES-SIMPLEX VIRUS-1 ENCODES A FUNCTION THAT FACILITATES NUCLEOCAPSID ENVELOPMENT AND EGRESS FROM CELLS [J].

BAINES, JD ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1992, 66 (08) :5168-5174

[3] THE UL20 GENE OF HERPES-SIMPLEX VIRUS-1 ENCODES A FUNCTION NECESSARY FOR VIRAL EGRESS [J].

BAINES, JD ;

WARD, PL ;

CAMPADELLIFIUME, G ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1991, 65 (12) :6414-6424

[4] THE UL10 GENE OF HERPES-SIMPLEX VIRUS-1 ENCODES A NOVEL VIRAL GLYCOPROTEIN, GM, WHICH IS PRESENT IN THE VIRION AND IN THE PLASMA-MEMBRANE OF INFECTED-CELLS [J].

BAINES, JD ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1993, 67 (03) :1441-1452

[5] THE UNIQUE SEQUENCE OF THE HERPES-SIMPLEX VIRUS-1 L COMPONENT CONTAINS AN ADDITIONAL TRANSLATED OPEN READING FRAME DESIGNATED UL49.5 [J].

BARKER, DE ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1992, 66 (01) :562-566

[6] FRAGMENTATION AND DISPERSAL OF GOLGI PROTEINS AND REDISTRIBUTION OF GLYCOPROTEINS AND GLYCOLIPIDS PROCESSED THROUGH THE GOLGI-APPARATUS AFTER INFECTION WITH HERPES-SIMPLEX VIRUS-1 [J].

CAMPADELLI, G ;

BRANDIMARTI, R ;

DILAZZARO, C ;

WARD, PL ;

ROIZMAN, B ;

TORRISI, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :2798-2802

[7] THE PRODUCT OF THE U(L)31 GENE OF HERPES-SIMPLEX VIRUS-1 IS A NUCLEAR PHOSPHORPROTEIN WHICH PARTITIONS WITH THE NUCLEAR MATRIX [J].

CHANG, YE ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1993, 67 (11) :6348-6356

[8] THE GAMMA-134.5 GENE OF HERPES-SIMPLEX VIRUS-1 PRECLUDES NEUROBLASTOMA-CELLS FROM TRIGGERING TOTAL SHUTOFF OF PROTEIN-SYNTHESIS CHARACTERISTIC OF PROGRAMMED CELL-DEATH IN NEURONAL CELLS [J].

CHOU, J ;

ROIZMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3266-3270

[9] THE HERPES-SIMPLEX VIRUS-1 GENE FOR ICP34.5, WHICH MAPS IN INVERTED REPEATS, IS CONSERVED IN SEVERAL LIMITED-PASSAGE ISOLATES BUT NOT IN STRAIN 17SYN+ [J].

CHOU, J ;

ROIZMAN, B .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1014-1020

[10] AN AUTOPHOSPHORYLATING BUT NOT TRANSPHOSPHORYLATING ACTIVITY IS ASSOCIATED WITH THE UNIQUE N-TERMINUS OF THE HERPES-SIMPLEX VIRUS TYPE-1 RIBONUCLEOTIDE REDUCTASE LARGE SUBUNIT [J].

CONNER, J ;

COOPER, J ;

FURLONG, J ;

CLEMENTS, JB .

JOURNAL OF VIROLOGY, 1992, 66 (12) :7511-7516

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