NEW CHIRAL LIGAND FOR OPTICALLY-ACTIVE BETA-HYDROXY ESTERS - SYNTHESIS BY ENANTIOSELECTIVE REFORMATSKY REACTIONS

被引：33

作者：

PINI, D ^{[1
]}

MASTANTUONO, A ^{[1
]}

SALVADORI, P ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO CHIM & CHIM IND,CNR,CTR STUDIO MACROMOLEC STEREORDINATE & OTTICAMENTE,I-56126 PISA,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(00)86254-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The cheap commercially available (1S,2S)-1-phenyl-2-amino-1,3-propanediol 2 appears to be a convenient precursor for the synthesis of chiral auxiliaries for the preparation of optically active beta-hydroxy esters by asymmetric Reformatsky reactions. The N,N-dimethyl derivative of TBDMS-2 gave products with enantiomeric excesses up to 65 %.

引用

页码：1875 / 1876

页数：2

共 4 条

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[2]

Heathcock C.H., 1984, ASYMMETRIC SYNTHESIS, V3, P144

[3]

MEYERS AI, 1982, J AM CHEM SOC WASHIN

[4] ASYMMETRIC-SYNTHESIS OF BETA-HYDROXYESTERS BY THE ENANTIOSELECTIVE REFORMATSKY REACTION IN THE PRESENCE OF CHIRAL AMINOALCOHOLS [J].

SOAI, K ;

KAWASE, Y .

TETRAHEDRON-ASYMMETRY, 1991, 2 (08) :781-784

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