HYPERGLYCEMIA PER SE (INSULIN AND GLUCAGON WITHDRAWN) CAN INHIBIT HEPATIC GLUCOSE PRODUCTION IN MAN

被引:119
作者
LILJENQUIST, JE [1 ]
MUELLER, GL [1 ]
CHERRINGTON, AD [1 ]
PERRY, JM [1 ]
RABINOWITZ, D [1 ]
机构
[1] VANDERBILT UNIV, SCH MED, DEPT PHYSIOL, NASHVILLE, TN 37232 USA
关键词
D O I
10.1210/jcem-48-1-171
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We examined the effect of hyperglycemia per se on net splanchnic glucose balance. In 2 groups of normal postabsorptive men who had undergone hepatic vein catheterization, somatostatin was administered to block endogenous insulin and glucagon secretion. Exogenous glucose was infused in both groups to maintain euglycemia for 2 h in one group (n = 7) and to induce hyperglycemia of 220-240 mg/dl after 30 minutes of euglycemia in the second group (n = 4). In both groups the induction of insulinopenia and glucagonopenia with euglycemia maintained resulted in an initial 75% fall in net splanchnic glucose production (NSGP). In the group in which euglycemia was maintained NSGP returned to basal rates (157 ± 31 mg/min) within 2 h. However, in the group in which hyperglycemia was induced, NSGP did not return to basal rates but remained suppressed (28 ± 4 mg/min) for the duration of the study. These data in normal man indicate that hyperglycemia per se with insulin and glucagon acutely withdrawn can suppress splanchnic glucose production but does not induce net splanchnic glucose storage. © 1979 by The Endocrine Society.
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页码:171 / 175
页数:5
相关论文
共 17 条
[1]  
ANDRES R, 1966, AUTOMAT ANAL CHEM, P486
[2]   EFFECT OF GLUCAGON ON GLUCOSE PRODUCTION DURING INSULIN DEFICIENCY IN DOG [J].
CHERRINGTON, AD ;
LACY, WW ;
CHIASSON, JL .
JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (03) :664-677
[3]  
CHERRINGTON AD, AM J PHYSL
[4]   GLUCONEOGENESIS FROM ALANINE IN NORMAL POSTABSORPTIVE MAN - INTRAHEPATIC STIMULATORY EFFECT OF GLUCAGON [J].
CHIASSON, JL ;
LILJENQUIST, JE ;
SINCLAIRSMITH, BC ;
LACY, WW .
DIABETES, 1975, 24 (06) :574-584
[5]   CONTROL OF RAT LIVER GLYCOGEN SYNTHETASE AND PHOSPHORYLASE ACTIVITIES BY GLUCOSE [J].
GLINSMANN, W ;
PAUK, G ;
HERN, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1970, 39 (04) :774-+
[6]   INTRINSIC REGULATION OF GLUCOSE OUTPUT BY RAT LIVER [J].
GLINSMANN, WH ;
HERN, EP ;
LYNCH, A .
AMERICAN JOURNAL OF PHYSIOLOGY, 1969, 216 (04) :698-+
[7]   GLYCOGEN SYNTHESIS IN PERFUSED LIVER OF STARVED RAT [J].
HEMS, DA ;
TAYLOR, EA ;
WHITTON, PD .
BIOCHEMICAL JOURNAL, 1972, 129 (03) :529-&
[8]   CONTROL OF GLYCOGEN-METABOLISM IN LIVER [J].
HERS, HG .
ANNUAL REVIEW OF BIOCHEMISTRY, 1976, 45 :167-189
[9]   EFFECT OF GLUCOSE AND OF POTASSIUM-IONS ON INTERCONVERSION OF 2 FORMS OF GLYCOGEN-PHOSPHORYLASE AND OF GLYCOGEN-SYNTHETASE IN ISOLATED RAT-LIVER PREPARATIONS [J].
HUE, L ;
BONTEMPS, F ;
HERS, HG .
BIOCHEMICAL JOURNAL, 1975, 152 (01) :105-114
[10]  
Hultman E., 1971, MUSCLE METABOLISM EX, P143, DOI 10.1007/978-1-4613-4609-8_14