SYNTHESIS OF THIENO- AND FURO-PYRIMIDINETHIONES

被引：26

作者：

MANHAS, MS

RAO, VV

SEETHARA.PA

SUCCARDI, D

PAZDERA, J

机构：

[1] Department of Chemistry and Chemical Engineering, Stevens Institute of Technology, Hoboken

来源：

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1969年 / 14期

关键词：

D O I：

10.1039/j39690001937

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted thiophens carrying adjacent amino- and cyano-groups have been converted into the corresponding pyrimidinethione derivatives in 30-70% yield by condensation with thioamides. Acylation of the thiophen followed by cyclisation in acidic solution gave the corresponding pyrimidones. The same reactions were used successfully with analogous furan compounds.

引用

页码：1937 / &

共 12 条

[1] Bogert M.T., 1902, J AM CHEM SOC, V24, P1031
[2] BURCHENAL JOSEPH H., 1954, ANN NEW YORK ACAD SCI, V60, P359
[3] HETEROCYCLEN AUS CH-ACIDEN NITRILEN .9. UBER DIE REAKTION VON ALPHA-HYDROXY-KETONEN MIT MALODINITRIL
GEWALD, K
[J]. CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (03): : 1002 - &
[4] 2-AMINO-THIOPHENE AUS METHYLENAKTIVEN NITRILEN CARBONYLVERBINDUNGEN UND SCHWEFEL
GEWALD, K
SCHINKE, E
BOTTCHER, H
[J]. CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (01): : 94 - &
[5] Some reactions of amidines with derivtives of malonic acid
Kenner, GW
Lythgoe, B
Todd, AR
Topham, A
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1943, : 388 - 390
[6] ANTITUMOR ACTIVITY + STRUCTURAL RELATIONSHIPS OF PURINE DERIVATIVES + RELATED COMPOUNDS AGAINST NEOPLASMS IN EXPERIMENTAL ANIMALS
ROBINS, RK
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (02) : 186 - +
[7] SKIPPER HE, 1959, CANCER RES, V19, P425
[8] SKIPPER HE, 1957, P SOC EXP BIOL MED, V95, P135
[9] CONVENIENT SYNTHESIS OF FUSED 4-MERCAPTOPYRIMIDINES FROM O-AMINONITRILES
TAYLOR, EC
ZOLTEWICZ, JA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1961, 83 (01) : 248 - &
[10] HETEROCYCLIC SYNTHESES FROM O-AMINONITRILES .3/. SYNTHESIS OF SOME DIAZA STEROIDS
TAYLOR, EC
SHVO, Y
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (05) : 1719 - &

← 1 2 →