GENETIC-VARIATION BETWEEN MICE IN THEIR METABOLISM OF COUMARIN AND ITS DERIVATIVES

被引：36

作者：

LUSH, IE

ANDREWS, KM

机构：

[1] Department of Genetics, Royal Free Hospital School of Medicine, London WC1N 1BP

来源：

GENETICAL RESEARCH | 1978年 / 31卷 / 02期

关键词：

D O I：

10.1017/S0016672300017936

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Adult females from 19 strains of mice were injected with either coumarin or 7-ethoxycoumarin and the urinary excretion of the umbelliferone produced by the metabolism of these substances was measured. With the exception of C57L the strains fell into three classes as follows: high metabolizers (DBA/1 and DBA/2), medium metabolizers (CBA, 129/Rr, NZB and NZW) and low metabolizers (the other 12 strains). The difference in metabolizing ability between the medium group and the low group of strains was also evident when the 4-methyl derivatives of the same two substances were used. However with the 4-methyl derivatives there was no difference in metabolizing ability between the medium group and the high group. The results are interpreted as evidence that the gene Coh on chromosome 7 comprises two closely linked genes which determine cytochrome P-450 isozymes with different substrate specificities. © 1978, Cambridge University Press. All rights reserved.

引用

页码：177 / 186

页数：10

共 19 条

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