ANTIMICROBIAL ACTIVITIES OF POLYETHER COMPOUNDS OF DINOFLAGELLATE ORIGINS

被引：32

作者：

NAGAI, H

SATAKE, M

YASUMOTO, T

机构：

[1] Taiyo Central R and D Institute, Taiyo Fishery Co. LTD., Tokyo, 3-2-9, Tsukishima, Chuo-ku

[2] Faculty of Agriculture, Tohoku University, Sendai, 981

来源：

JOURNAL OF APPLIED PHYCOLOGY | 1990年 / 2卷 / 04期

关键词：

POLYETHER; ANTIMICROBIAL ACTIVITY; DINOFLAGELLATE; ANTIFUNGALS; CHEMICAL MODIFICATION;

D O I：

10.1007/BF02180919

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Twelve polyether compounds originating from dinoflagellates were tested for growth-inhibiting activities against Aspergillus niger, Penicillium funiculosum, Candida rugosa, Escherichia coli, Bacillus megaterium and Staphylococcus aureus by a paper disc method. These polyethers represent six groups of different skeletons and originate from three species; Prorocentrum lima, Dinophysis fortii and Gambierdiscus toxicus. Potent antifungal activities were observed with okadaic acid and its two congeners, desulfated yessotoxin, and ciguatoxin but not with okadaic acid esters, prorocentrolide, pectenotoxin-1, yessotoxin, maitotoxin, and desulphated maitotoxin. The antifungal activities and mouse lethalities of the polyethers were markedly affected by slight modification of their structures. Antibacterial potency of the tested compounds was not significant.

引用

页码：305 / 308

页数：4

共 16 条

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