MEMORY FORMATION AS RELATED TO GENOTYPIC OR EXPERIMENTAL VARIATIONS OF HIPPOCAMPAL CHOLINERGIC ACTIVITY IN MICE

被引：34

作者：

JAFFARD, R ^{[1
]}

DESTRADE, C ^{[1
]}

DURKIN, T ^{[1
]}

EBEL, A ^{[1
]}

机构：

[1] CNRS,CTR NEUROCHIM,F-67085 STRASBOURG,FRANCE

来源：

PHYSIOLOGY & BEHAVIOR | 1979年 / 22卷 / 06期

关键词：

Cholinergic mechanisms; Electrical stimulation; Hippocampus; Memory; Retrieval; Strain differences;

D O I：

10.1016/0031-9384(79)90262-2

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Two successive experiments were designed to compare learning and retention and the post-training effect of hippocampal electrical stimulation on retention of a lever-press conditioning among several groups of mice. In parallel experiments, we studied the enzymes involved in acetylcholine metabolism in the dorsal hippocampus. Results showed that either a genotypic or an experimentally induced decrease of choline acetyltransferase activity weakened both long-term retention and the facilitatory effect of post-trial stimulation but improved short-term retention. The role of hippocampal cholinergic synapses in response execution and memory consolidation is discussed. © 1979.

引用

页码：1093 / 1096

页数：4

共 29 条

[1] POST-TRIAL HIPPOCAMPAL AND LATERAL HYPOTHALAMIC ELECTRICAL-STIMULATION - FACILITATION ON LONG-TERM-MEMORY OF APPETITIVE AND AVOIDANCE-LEARNING TASKS [J].