COMPARISON OF THE EFFECT OF LORGLUMIDE ON PANCREATIC GROWTH STIMULATED BY CAMOSTATE IN RAT AND HAMSTER

We conducted a 14 day experiment in which we administered camostate (a trypsin inhibitor) and cholecystokinin alone or in combination with lorglumide, a cholecystokinin receptor antagonist, to both rats and hamsters. Plasma cholecystokinin levels were 21.7±3.2 pM and 19.6±2.5 pM with camostate, 16.3±2.4 pM and 14.8±2.2 pM with exogenous cholecystokinin, and 3.7±0.4 pM and 4.2±1.0 pM in control experiments in rats and hamsters, respectively. Both cholecystokinin and camostate were found to promote pancreatic growth in rats (18±4 and 111±7%, respectively) and hamsters (76±18 and 61±12%, respectively). Although lorglumide caused a decrease of this effect of camostate in both rats (78±5%) and hamsters (25±10%),it only became significant in rats. We therefore conclude that there are important interspecies differences in the role cholecystokinin plays in mediating the trophic effects of trypsin inhibitors on the pancreas. © 1990.