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SPECIFIC BINDING OF VASCULOTROPIN TO BOVINE BRAIN CAPILLARY ENDOTHELIAL-CELLS
被引:28
作者
:
PLOUET, J
论文数:
0
引用数:
0
h-index:
0
机构:
U86 INSERM, Centre des Cordeliers, 75006 Paris, 15, rue de l'Ecole de Medicine
PLOUET, J
MOUKADIRI, H
论文数:
0
引用数:
0
h-index:
0
机构:
U86 INSERM, Centre des Cordeliers, 75006 Paris, 15, rue de l'Ecole de Medicine
MOUKADIRI, H
机构
:
[1]
U86 INSERM, Centre des Cordeliers, 75006 Paris, 15, rue de l'Ecole de Medicine
来源
:
BIOCHIMIE
|
1990年
/ 72卷
/ 01期
关键词
:
angiogenic growth factors;
radioreceptor assay;
vasculotropin;
D O I
:
10.1016/0300-9084(90)90172-D
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
Recently, a new growth factor was purified to homogeneity; its biological activity appeared to be restricted to vascular endothelial derived cells. As it was also angiogenic in vivo, it was provisionally named vasculotropin. An iodination procedure used to label vasculotropin did not damage the molecule; it was thus possible to undertake binding studies. The binding of iodinated vasculotropin to bovine brain capillary endothelial cells reached saturation at 7 ng/ml and half maximal binding occurred at 1.5 ng/ml. Scatchard analysis of the data demonstrated 2 classes of binding sites with apparent dissociation constants of 4 and 41 pM and 600 and 4 100 sites per cell respectively. The interaction was specific since an excess of unlabelled vasculotropin, but no Fibroblast Growth Factor or Transforming Growth Factor Beta almost totally abolished the binding of the tracer. A sensitive radioreceptor-assay convenient for measuring vasculotropin in biological samples is described. © 1990.
引用
收藏
页码:51 / 55
页数:5
相关论文
共 21 条
[1]
AHARONOV A, 1978, J BIOL CHEM, V253, P3970
[2]
BINDING, INTERNALIZATION, AND DEGRADATION OF BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN MICROVASCULAR ENDOTHELIAL-CELLS
BIKFALVI, A
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
BIKFALVI, A
DUPUY, E
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
DUPUY, E
INYANG, AL
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
INYANG, AL
FAYEIN, N
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
FAYEIN, N
LESECHE, G
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
LESECHE, G
COURTOIS, Y
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
COURTOIS, Y
TOBELEM, G
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
TOBELEM, G
[J].
EXPERIMENTAL CELL RESEARCH,
1989,
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84
[3]
ACIDIC FIBROBLAST GROWTH-FACTOR (FGF) FROM BOVINE BRAIN - AMINO-TERMINAL SEQUENCE AND COMPARISON WITH BASIC FGF
BOHLEN, P
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
BOHLEN, P
ESCH, F
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
ESCH, F
BAIRD, A
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
BAIRD, A
GOSPODAROWICZ, D
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
GOSPODAROWICZ, D
[J].
EMBO JOURNAL,
1985,
4
(08)
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-
1956
[4]
BOWENPOPE DF, 1982, J BIOL CHEM, V257, P5161
[5]
CHEIFETZ S, 1986, J BIOL CHEM, V261, P9972
[6]
PITUITARY FOLLICULAR CELLS SECRETE A NOVEL HEPARIN-BINDING GROWTH-FACTOR SPECIFIC FOR VASCULAR ENDOTHELIAL-CELLS
FERRARA, N
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
FERRARA, N
HENZEL, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
HENZEL, WJ
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1989,
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(02)
: 851
-
858
[7]
ANGIOGENIC FACTORS
FOLKMAN, J
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
FOLKMAN, J
KLAGSBRUN, M
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
KLAGSBRUN, M
[J].
SCIENCE,
1987,
235
(4787)
: 442
-
447
[8]
FROLIK CA, 1984, J BIOL CHEM, V259, P995
[9]
ISOLATION AND CHARACTERIZATION OF A VASCULAR ENDOTHELIAL-CELL MITOGEN PRODUCED BY PITUITARY-DERIVED FOLLICULO STELLATE CELLS
GOSPODAROWICZ, D
论文数:
0
引用数:
0
h-index:
0
机构:
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
GOSPODAROWICZ, D
ABRAHAM, JA
论文数:
0
引用数:
0
h-index:
0
机构:
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
ABRAHAM, JA
SCHILLING, J
论文数:
0
引用数:
0
h-index:
0
机构:
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
SCHILLING, J
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1989,
86
(19)
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-
7315
[10]
GOSPODAROWICZ D, 1986, J CELL PHYSL, P127
←
1
2
3
→
共 21 条
[1]
AHARONOV A, 1978, J BIOL CHEM, V253, P3970
[2]
BINDING, INTERNALIZATION, AND DEGRADATION OF BASIC FIBROBLAST GROWTH-FACTOR IN HUMAN MICROVASCULAR ENDOTHELIAL-CELLS
BIKFALVI, A
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
BIKFALVI, A
DUPUY, E
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
DUPUY, E
INYANG, AL
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
INYANG, AL
FAYEIN, N
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
FAYEIN, N
LESECHE, G
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
LESECHE, G
COURTOIS, Y
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
COURTOIS, Y
TOBELEM, G
论文数:
0
引用数:
0
h-index:
0
机构:
HOP LARIBOISIERE,INSERM,U150,F-75475 PARIS 10,FRANCE
TOBELEM, G
[J].
EXPERIMENTAL CELL RESEARCH,
1989,
181
(01)
: 75
-
84
[3]
ACIDIC FIBROBLAST GROWTH-FACTOR (FGF) FROM BOVINE BRAIN - AMINO-TERMINAL SEQUENCE AND COMPARISON WITH BASIC FGF
BOHLEN, P
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
BOHLEN, P
ESCH, F
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
ESCH, F
BAIRD, A
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
BAIRD, A
GOSPODAROWICZ, D
论文数:
0
引用数:
0
h-index:
0
机构:
SALK INST BIOL STUDIES,SAN DIEGO,CA 92138
GOSPODAROWICZ, D
[J].
EMBO JOURNAL,
1985,
4
(08)
: 1951
-
1956
[4]
BOWENPOPE DF, 1982, J BIOL CHEM, V257, P5161
[5]
CHEIFETZ S, 1986, J BIOL CHEM, V261, P9972
[6]
PITUITARY FOLLICULAR CELLS SECRETE A NOVEL HEPARIN-BINDING GROWTH-FACTOR SPECIFIC FOR VASCULAR ENDOTHELIAL-CELLS
FERRARA, N
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
FERRARA, N
HENZEL, WJ
论文数:
0
引用数:
0
h-index:
0
机构:
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
GENENTECH INC, DEPT PROT CHEM, San Francisco, CA 94080 USA
HENZEL, WJ
[J].
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1989,
161
(02)
: 851
-
858
[7]
ANGIOGENIC FACTORS
FOLKMAN, J
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
FOLKMAN, J
KLAGSBRUN, M
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA
KLAGSBRUN, M
[J].
SCIENCE,
1987,
235
(4787)
: 442
-
447
[8]
FROLIK CA, 1984, J BIOL CHEM, V259, P995
[9]
ISOLATION AND CHARACTERIZATION OF A VASCULAR ENDOTHELIAL-CELL MITOGEN PRODUCED BY PITUITARY-DERIVED FOLLICULO STELLATE CELLS
GOSPODAROWICZ, D
论文数:
0
引用数:
0
h-index:
0
机构:
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
GOSPODAROWICZ, D
ABRAHAM, JA
论文数:
0
引用数:
0
h-index:
0
机构:
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
ABRAHAM, JA
SCHILLING, J
论文数:
0
引用数:
0
h-index:
0
机构:
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
CALIF BIOTECHNOL INC,MT VIEW,CA 94043
SCHILLING, J
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1989,
86
(19)
: 7311
-
7315
[10]
GOSPODAROWICZ D, 1986, J CELL PHYSL, P127
←
1
2
3
→