NEUROPEPTIDE-Y ACTIVATES INWARDLY-RECTIFYING K+-CHANNELS IN C-CELLS OF AMPHIBIAN SYMPATHETIC-GANGLIA

被引：22

作者：

ZIDICHOUSKI, JA ^{[1
]}

CHEN, H ^{[1
]}

SMITH, PA ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT PHARMACOL,975 MED SCI BLDG,EDMONTON T6G 2H7,ALBERTA,CANADA

来源：

NEUROSCIENCE LETTERS | 1990年 / 117卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Adrenaline; Amphibian; Autonomic nervous system; Inward rectification; K[!sup]+[!/sup]-channel; Muscarinic response; Neuropeptide Y; Sympathetic ganglion;

D O I：

10.1016/0304-3940(90)90130-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropeptide Y (NPY) is found in the C-cells yet is absent from the B-cells of amphibian sympathetic ganglia. The effects of this peptide on both cell types were studied using the whole-cell patch-clamp recording technique. Although NPY had little effect on the B-cells, it opened inwardly-rectifying K+-channels in C-cells. This effect of the peptide on C-cell K+-channels was similar to that produced by muscarine and adrenaline and may be related to autoreceptor function. © 1990.

引用

页码：123 / 128

页数：6

共 14 条

[1] PHARMACOLOGICAL INHIBITION OF THE M-CURRENT [J].

ADAMS, PR ;

BROWN, DA ;

CONSTANTI, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 332 (NOV) :223-262

[2] NEUROPEPTIDE-Y DISTRIBUTION IN HUMAN-BRAIN [J].

ADRIAN, TE ;

ALLEN, JM ;

BLOOM, SR ;

GHATEI, MA ;

ROSSOR, MN ;

ROBERTS, GW ;

CROW, TJ ;

TATEMOTO, K ;

POLAK, JM .

NATURE, 1983, 306 (5943) :584-586

[3] ADRENALINE DEPOLARIZATION IN PARAVERTEBRAL SYMPATHETIC NEURONS OF BULLFROGS [J].

AKASU, T .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1988, 411 (01) :80-87

[4] NEUROPEPTIDE-Y DISTRIBUTION IN THE RAT-BRAIN [J].

ALLEN, YS ;

ADRIAN, TE ;

ALLEN, JM ;

TATEMOTO, K ;

CROW, TJ ;

BLOOM, SR ;

POLAK, JM .

SCIENCE, 1983, 221 (4613) :877-879

[5]

HORN JP, 1987, J NEUROSCI, V7, P1717

[6] INTERACTION BETWEEN NEUROPEPTIDE-Y AND NORADRENALINE ON CENTRAL CATECHOLAMINE NEURONS [J].

ILLES, P ;

REGENOLD, JT .

NATURE, 1990, 344 (6261) :62-63

[7] A RECEPTOR FOR PROTONS IN THE NERVE-CELL MEMBRANE [J].

KRISHTAL, OA ;

PIDOPLICHKO, VI .

NEUROSCIENCE, 1980, 5 (12) :2325-2327

[8] NEUROPEPTIDE-Y (NPY)-LIKE IMMUNOREACTIVITY IN PERIPHERAL NORADRENERGIC NEURONS AND EFFECTS OF NPY ON SYMPATHETIC FUNCTION [J].

LUNDBERG, JM ;

TERENIUS, L ;

HOKFELT, T ;

MARTLING, CR ;

TATEMOTO, K ;

MUTT, V ;

POLAK, J ;

BLOOM, S ;

GOLDSTEIN, M .

ACTA PHYSIOLOGICA SCANDINAVICA, 1982, 116 (04) :477-480

[9] CORELEASE OF NEUROPEPTIDE-Y AND CATECHOLAMINES UPON ADRENAL ACTIVATION IN THE CAT [J].

LUNDBERG, JM ;

FRIED, G ;

PERNOW, J ;

THEODORSSONNORHEIM, E .

ACTA PHYSIOLOGICA SCANDINAVICA, 1986, 126 (02) :231-238

[10] DRUG RECEPTORS AND THE INHIBITION OF NERVE-CELLS [J].

NORTH, RA .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 98 (01) :13-28

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