ANALOGS OF THE INSECT MYOTROPIC PEPTIDE PROCTOLIN - SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES

被引:61
作者
STARRATT, AN
BROWN, BE
机构
[1] Agriculture Canada, Research Institute, University Sub Post Office, London
关键词
D O I
10.1016/0006-291X(79)91152-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fifteen pentapeptides structurally related to the insect myotropic substance proctolin synthesized by solution methods were assayed for proctolin activity on cockroach proctodeal muscle. [Phe(p-OMe)2]-Proctolin was almost three times as potent as the natural pentapeptide; other analogs ranged from 15% as active to almost inactive. Related shorter chain-length peptides had little or no activity. None of the synthetic peptides acted as antagonists. © 1979.
引用
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页码:1125 / 1130
页数:6
相关论文
共 15 条
[1]   ISOLATION OF PROCTOLIN, A MYOTROPIC PEPTIDE, FROM PERIPLANETA-AMERICANA [J].
BROWN, BE ;
STARRATT, AN .
JOURNAL OF INSECT PHYSIOLOGY, 1975, 21 (11) :1879-1881
[2]   OCCURRENCE OF PROCTOLIN IN 6 ORDERS OF INSECTS [J].
BROWN, BE .
JOURNAL OF INSECT PHYSIOLOGY, 1977, 23 (07) :861-864
[3]   PROCTOLIN - PEPTIDE TRANSMITTER CANDIDATE IN INSECTS [J].
BROWN, BE .
LIFE SCIENCES, 1975, 17 (08) :1241-1252
[4]   NEUROMUSCULAR TRANSMITTER SUBSTANCE IN INSECT VISCERAL MUSCLE [J].
BROWN, BE .
SCIENCE, 1967, 155 (3762) :595-+
[5]   COMPARATIVE PHARMACOLOGICAL PROPERTIES OF MUSCLE FUNCTION IN FOREGUT AND HINDGUT OF COCKROACH LEUCOPHAEA-MADERAE [J].
COOK, BJ ;
HOLMAN, GM .
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY, 1978, 61 (02) :291-295
[6]   OVIDUCT MUSCULATURE OF HORSEFLY, TABANUS-SULCIFRONS, AND ITS RESPONSE TO 5-HYDROXYTRYPTAMINE AND PROCTOLIN [J].
COOK, BJ ;
MEOLA, S .
PHYSIOLOGICAL ENTOMOLOGY, 1978, 3 (04) :273-280
[7]  
GRZONKA Z, 1974, SYNTHESIS-STUTTGART, P661
[8]   CONVENIENT PREPARATIVE METHOD FOR ESTERS OF AMINO-ACIDS [J].
MACLAREN, JA .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1972, 25 (06) :1293-&
[9]   MODIFIED TECHNIQUE FOR QUANTITATIVE-ANALYSIS OF AMINO-ACIDS BY GAS-CHROMATOGRAPHY USING HEPTAFLUOROBUTYRIC N-PROPYL DERIVATIVES [J].
MARCH, JF .
ANALYTICAL BIOCHEMISTRY, 1975, 69 (02) :420-442
[10]   EXPERIMENTAL STUDIES UPON A BUNDLE OF TONIC FIBERS IN THE LOCUST EXTENSOR TIBIALIS MUSCLE [J].
MAY, TE ;
BROWN, BE ;
CLEMENTS, AN .
JOURNAL OF INSECT PHYSIOLOGY, 1979, 25 (02) :169-181