LEAD-INDUCED BEHAVIORAL IMPAIRMENT ON A SPATIAL DISCRIMINATION REVERSAL TASK IN MONKEYS EXPOSED DURING DIFFERENT PERIODS OF DEVELOPMENT

A total of 52 monkeys (Macaca fascicularis) were dosed orally with vehicle or 1.5 mg/kg/day of lead on one of four dosing regimens (13 monkeys/group): Group 1, vehicle only; Group 2, dosed with lead from birth onward; Group 3, dosed with lead from birth to 400 days of age and vehicle thereafter; Group 4, dosed with vehicle from birth to 300 days of age and lead thereafter. Blood lead concentrations averaged 3-6 μg/dl when monkeys were not being dosed with lead, 32-36 μg/dl when being dosed with lead having access to infant formula, and 19-26 μg/dl when being dosed with lead after weaning from infant formula. When monkeys were 7-8 years old, they were tested on three spatial discrimination reversal tasks: no irrelevant cues, irrelevant form cues, and irrelevant form and color cues. Fifteen reversals were run for each task. Only Group 2 was impaired in the absence of irrelevant cues, while all three treated groups were impaired in the presence of irrelevant cues. These results are in contrast to results from a series of nonspatial discrimination reversal tasks in these monkeys in which Groups 2 and 4 were impaired and Group 3 was unimpaired. The present results are in agreement with results from another spatial task, delayed alternation, in which all three treated groups were impaired. © 1990.