STEREOSELECTIVE SYNTHESIS OF CIS-SUBSTITUTED AZETIDINONES FROM PENICILLIN - A FORMAL TOTAL SYNTHESIS OF LORACARBEF

被引：16

作者：

DEETER, JB ^{[1
]}

HALL, DA ^{[1
]}

JORDAN, CL ^{[1
]}

JUSTICE, RM ^{[1
]}

KINNICK, MD ^{[1
]}

MORIN, JM ^{[1
]}

PASCHAL, JW ^{[1
]}

TERNANSKY, RJ ^{[1
]}

机构：

[1] ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,INDIANAPOLIS,IN 46285

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)93376-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of chiral azetidinones bearing a carbon-carbon bond at the 4-position is described. The preparation involves a stereoselective alkylation-reduction of a silylated 4-phenylsulfonyl azetidinone. The utility of this method was demonstrated by a formal total synthesis of loracarbef.

引用

页码：3051 / 3054

页数：4

共 17 条

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