PHAGOCYTE TRANSPORT AS MECHANISM FOR ENHANCED THERAPEUTIC ACTIVITY OF LIPOSOMAL AMPHOTERICIN-B

被引:32
作者
MEHTA, RT
MCQUEEN, TJ
KEYHANI, A
LOPEZBERESTEIN, G
机构
[1] Immunobiology and Drug, Carriers Section, Division of Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX
关键词
AMPHOTERICIN B; LIPOSOMES; PHAGOCYTES;
D O I
10.1159/000239202
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Liposomal amphotericin B (L-AmB) is emerging as one of the most attractive new antifungal agents. We have attempted to show that phagocytic cells circulating in blood play an important role in transport and accumulation of L-AmB at inflammatory sites in vivo. Free AmB or L-AmB was injected intravenously to mice, and the amount of AmB in peritoneal exudate cells was quantitated by high-performance liquid chromatography. Higher levels of AmB were detected in a higher number of mice injected with L-AmB. The presence of L-AmB in inflammatory peritoneal cells after intravenous administration of fluorescence-labeled L-AmB also suggested that macrophages play an important role in the transport of intravenously administered L AmB to inflammatory sites.
引用
收藏
页码:256 / 264
页数:9
相关论文
共 19 条
  • [1] DELIVERY OF LIPOSOME-ENCAPSULATED DRUGS TO MACROPHAGES
    ALVING, CR
    [J]. PHARMACOLOGY & THERAPEUTICS, 1983, 22 (03) : 407 - 424
  • [2] ANTILEISHMANIAL ACTIVITY OF LIPOSOME-ENCAPSULATED AMPHOTERICIN-B IN HAMSTERS AND MONKEYS
    BERMAN, JD
    HANSON, WL
    CHAPMAN, WL
    ALVING, CR
    LOPEZBERESTEIN, G
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (06) : 847 - 851
  • [3] DISTRIBUTION AND ACTIVITY OF AMPHOTERICIN-B IN HUMANS
    CHRISTIANSEN, KJ
    BERNARD, EM
    GOLD, JWM
    ARMSTRONG, D
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1985, 152 (05) : 1037 - 1043
  • [4] INVITRO ANTIFUNGAL ACTIVITIES OF AMPHOTERICIN-B AND LIPOSOME-ENCAPSULATED AMPHOTERICIN-B
    HOPFER, RL
    MILLS, K
    MEHTA, R
    LOPEZBERESTEIN, G
    FAINSTEIN, V
    JULIANO, RL
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 25 (03) : 387 - 389
  • [5] SELECTIVE TOXICITY AND ENHANCED THERAPEUTIC INDEX OF LIPOSOMAL POLYENE ANTIBIOTICS IN SYSTEMIC FUNGAL-INFECTIONS
    JULIANO, RL
    LOPEZBERESTEIN, G
    HOPFER, R
    MEHTA, R
    MEHTA, K
    MILLS, K
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 446 : 390 - 402
  • [6] TREATMENT OF HEPATOSPLENIC CANDIDIASIS WITH LIPOSOMAL-AMPHOTERICIN-B
    LOPEZBERESTEIN, G
    BODEY, GP
    FRANKEL, LS
    MEHTA, K
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (02) : 310 - 317
  • [7] TREATMENT OF SYSTEMIC FUNGAL-INFECTIONS WITH LIPOSOMAL AMPHOTERICIN-B
    LOPEZBERESTEIN, G
    BODEY, GP
    FAINSTEIN, V
    KEATING, M
    FRANKEL, LS
    ZELUFF, B
    GENTRY, L
    MEHTA, K
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1989, 149 (11) : 2533 - 2536
  • [8] LIPOSOMAL AMPHOTERICIN-B FOR THE TREATMENT OF SYSTEMIC FUNGAL-INFECTIONS IN PATIENTS WITH CANCER - A PRELIMINARY-STUDY
    LOPEZBERESTEIN, G
    FAINSTEIN, V
    HOPFER, R
    MEHTA, K
    SULLIVAN, MP
    KEATING, M
    ROSENBLUM, MG
    MEHTA, R
    LUNA, M
    HERSH, EM
    REUBEN, J
    JULIANO, RL
    BODEY, GP
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1985, 151 (04) : 704 - 710
  • [9] TREATMENT AND PROPHYLAXIS OF DISSEMINATED INFECTION DUE TO CANDIDA-ALBICANS IN MICE WITH LIPOSOME-ENCAPSULATED AMPHOTERICIN-B
    LOPEZBERESTEIN, G
    MEHTA, R
    HOPFER, RL
    MILLS, K
    KASI, L
    MEHTA, K
    FAINSTEIN, V
    LUNA, M
    HERSH, EM
    JULIANO, R
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1983, 147 (05) : 939 - 945
  • [10] PROPHYLAXIS OF CANDIDA-ALBICANS INFECTION IN NEUTROPENIC MICE WITH LIPOSOME-ENCAPSULATED AMPHOTERICIN-B
    LOPEZBERESTEIN, G
    HOPFER, RL
    MEHTA, R
    MEHTA, K
    HERSH, EM
    JULIANO, RL
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 25 (03) : 366 - 367