EFFECTS OF ALPHA-ARBUTIN AND BETA-ARBUTIN ON ACTIVITY OF TYROSINASES FROM MUSHROOM AND MOUSE MELANOMA

被引：167

作者：

FUNAYAMA, M ^{[1
]}

ARAKAWA, H ^{[1
]}

YAMAMOTO, R ^{[1
]}

NISHINO, T ^{[1
]}

SHIN, T ^{[1
]}

MURAO, S ^{[1
]}

机构：

[1] KUMAMOTO INST TECHNOL, FAC ENGN, DEPT APPL MICROBIAL TECHNOL, KUMAMOTO 860, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 01期

关键词：

D O I：

10.1271/bbb.59.143

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of alpha- and beta-arbutin on the activity of tyrosinases from mushroom and mouse melanoma were examined. alpha a-Arbutin was synthesized from hydroquinone and starch using glucoside synthetase (GSase). beta-Arbutin inhibited both tyrosinase activities from mushroom and mouse melanoma. alpha-Arbutin inhibited only the tyrosinase from mouse melanoma, 10 times as strongly as beta-arbutin. The IC50 of alpha-arbutin was 0.48 mM and its inhibitory mechanism was speculated to be mixed type inhibition, while that of beta-arbutin was noncompetitive.

引用

页码：143 / 144

页数：2

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