TNF-ALPHA GENE-EXPRESSION IS INDUCED IN NEURONS AFTER A HIPPOCAMPAL LESION

被引：67

作者：

TCHELINGERIAN, JL ^{[1
]}

VIGNAIS, L ^{[1
]}

JACQUE, C ^{[1
]}

机构：

[1] HOP LA PITIE SALPETRIERE,INSERM,U134,F-75651 PARIS 13,FRANCE

来源：

NEUROREPORT | 1994年 / 5卷 / 05期

关键词：

TNF-ALPHA; CYTOKINE; BRAIN; HIPPOCAMPUS; LESION; NEURONS; REGENERATION;

D O I：

10.1097/00001756-199401000-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE tumour necrosis factor alpha (TNF alpha) protein is normally absent in the brain. Its production in the nervous tissue during pathological processes is commonly attributed to cells of the macrophage or astroglial lineages. However, an immunoreactivity for TNF alpha has been observed recently in adult mouse brain after a lesion to the hippocampus. The identification, in the present study, of the cells responsible for this synthesis demonstrates a neuronal localization of the TNF alpha messenger RNA. We propose that neurone-produced TNF alpha acts as a modulatory effector in post-traumatic regenerative attempts of the brain.

引用

页码：585 / 588

页数：4

共 20 条

[1] CACHECTIN AND TUMOR-NECROSIS-FACTOR AS 2 SIDES OF THE SAME BIOLOGICAL COIN [J].

BEUTLER, B ;

CERAMI, A .

NATURE, 1986, 320 (6063) :584-588

[2]

CHUNG IY, 1990, J IMMUNOL, V144, P2999

[3] ANATOMICAL ORGANIZATION OF EXCITATORY AMINO-ACID RECEPTORS AND THEIR PATHWAYS [J].

COTMAN, CW ;

MONAGHAN, DT ;

OTTERSEN, OP ;

STORMMATHISEN, J .

TRENDS IN NEUROSCIENCES, 1987, 10 (07) :273-280

[4] INCREASED LEVELS OF MESSENGER-RNAS FOR NEUROTROPHIC FACTORS IN THE BRAIN DURING KINDLING EPILEPTOGENESIS [J].

ERNFORS, P ;

BENGZON, J ;

KOKAIA, Z ;

PERSSON, H ;

LINVALL, O .

NEURON, 1991, 7 (01) :165-176

[5] GABA-CONTAINING NEURONS IN THE SEPTUM CONTROL INHIBITORY INTERNEURONS IN THE HIPPOCAMPUS [J].

FREUND, TF ;

ANTAL, M .

NATURE, 1988, 336 (6195) :170-173

[6] LIMBIC SEIZURES INCREASE NEURONAL PRODUCTION OF MESSENGER-RNA FOR NERVE GROWTH-FACTOR [J].

GALL, CM ;

ISACKSON, PJ .

SCIENCE, 1989, 245 (4919) :758-761

[7] TUMOR NECROSIS FACTOR IDENTIFIED IN MULTIPLE-SCLEROSIS BRAIN [J].

HOFMAN, FM ;

HINTON, DR ;

JOHNSON, K ;

MERRILL, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (02) :607-612

[8] BDNF MESSENGER-RNA EXPRESSION IS INCREASED IN ADULT-RAT FOREBRAIN AFTER LIMBIC SEIZURES - TEMPORAL PATTERNS OF INDUCTION DISTINCT FROM NGF [J].

ISACKSON, PJ ;

HUNTSMAN, MM ;

MURRAY, KD ;

GALL, CM .

NEURON, 1991, 6 (06) :937-948

[9] BIOCHEMICAL AND MORPHOLOGICAL-CHANGES IN THE RAT HIPPOCAMPUS FOLLOWING TRANSECTION OF THE FIMBRIA-FORNIX [J].

LAHTINEN, H ;

MIETTINEN, R ;

YLINEN, A ;

HALONEN, T ;

RIEKKINEN, PJ .

BRAIN RESEARCH BULLETIN, 1993, 31 (3-4) :311-318

[10] PRODUCTION OF TUMOR NECROSIS FACTOR AND OTHER CYTOKINES BY ASTROCYTES STIMULATED WITH LIPOPOLYSACCHARIDE OR A NEUROTROPIC VIRUS [J].

LIEBERMAN, AP ;

PITHA, PM ;

SHIN, HS ;

SHIN, ML .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6348-6352

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