CORRELATION BETWEEN RATE OF DISSOLUTION AND ABSORPTION OF SALICYLAMIDE FROM TABLET AND SUSPENSION DOSAGE FORMS

被引：32

作者：

BATES, TR

LAMBERT, DA

JOHNS, WH

机构：

[1] Division of Pharmaceutics, School of Pharmacy, University of Connecticut, Storrs, Connecticut

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 12期

关键词：

Absorption rates—salicylamide dosage forms; Colorimetric analysis—spectrophotometer; Dissolution rates—salicylamide dosage forms; Salicylamide dosage forms—absorption‐dissolution rates; correlation;

D O I：

10.1002/jps.2600581209

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vivo absorption and the in vitro dissolution characteristics of a commercial suspension, a commercial tablet, and an experimental tablet formulation of the analgesic‐antipyretic drug salicylamide were compared. The results of the study demonstrated that the absorption of this drug is dissolution rate‐dependent and that the initial in vitro dissolution rate in 0.1 N HCl correlates well with the initial absorption rates of the test dosage forms in human subjects. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1468 / &

共 8 条

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