EMETINE RESISTANCE IN CHINESE-HAMSTER CELLS IS LINKED GENETICALLY WITH AN ALTERED 40S RIBOSOMAL-SUBUNIT PROTEIN, S20

被引：37

作者：

BOERSMA, D ^{[1
]}

MCGILL, SM ^{[1
]}

MOLLENKAMP, JW ^{[1
]}

ROUFA, DJ ^{[1
]}

机构：

[1] KANSAS STATE UNIV, DIV BIOL, MANHATTAN, KS 66506 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 01期

关键词：

D O I：

10.1073/pnas.76.1.415

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Emr-2 is an emetine-resistant (Emr) Chinese hamster ovary cell mutant that contains a single electrophoretically altered ribosomal protein, a component of its 40S ribosomal subunit (Boersma et/al, 1979). A genetic experiment designed to test linkage between the genes that specify the altered ribosomal protein, S20*, and emetine resistance in Emr clones that segregated from cultures of Emr-2 cells hybridized with emetine-sensitive cells is described. Emr and S20* phenotypes are due to mutations linked to the same chromosome in the Chinese hamster genome; probably due to the same mutation. Earlier speculations that the Emr locus in Chinese hamster cells is hemizygous are confirmed.

引用

页码：415 / 419

页数：5

共 16 条

[1]

BOERSMA D, 1979, J BIOL CHEM, V254

[2] NON-LINKAGE OF INDUCED MUTATIONS IN CHINESE-HAMSTER CELLS [J].