CHEMISTRY OF TRICARBONYL HEMIKETALS AND APPLICATION OF EVANS TECHNOLOGY TO THE TOTAL SYNTHESIS OF THE IMMUNOSUPPRESSANT (-)-FK-506

被引：179

作者：

JONES, TK

REAMER, RA

DESMOND, R

MILLS, SG

机构：

[1] Merck Sharp & Dohme Research Laboratories, Rahway New Jersey

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1990年 / 112卷 / 08期

关键词：

D O I：

10.1021/ja00164a023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Details of model studies probing the chemistry of the tricarbonyl region of FK-506 are presented, and their use in designing a successful route to this immunosuppressant is outlined. Applications of asymmetric oxazolidinone alkylation/aldol methodology to a convergent, highly flexible synthesis of the C10-C18 fragment and to improvements in the preparation of the C20-C34 segment are also discussed. © 1990, American Chemical Society. All rights reserved.

引用

页码：2998 / 3017

页数：20

共 62 条

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