COMPARATIVE BIOAVAILABILITY OF A MORPHINE SUPPOSITORY GIVEN RECTALLY AND IN A COLOSTOMY

被引:10
作者
HOJSTED, J
RUBECKPETERSEN, K
RASK, H
BIGLER, D
CHRISTENSEN, CB
机构
[1] HVIDOVRE UNIV HOSP,DEPT ANAESTHESIOL,DK-2650 HVIDOVRE,DENMARK
[2] HVIDOVRE UNIV HOSP,DEPT GASTROENTEROL SURG,DK-2650 HVIDOVRE,DENMARK
[3] UNIV COPENHAGEN,DEPT PHARMACOL,DK-1168 COPENHAGEN,DENMARK
关键词
Bioavailability; Colostomy dosing; Morphine; Rectal dosing; Suppository;
D O I
10.1007/BF02657056
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In eight patients with a colostomy, plasma morphine levels were followed for 8 h after administration of 20 mg morphine chloride as a suppository, first rectally and after at least 48 h via the colostomy. The bioavailability after administration in the colostomy showed very great variation; the mean value compared to rectal bioavailability was only 43% (range 0.1-127%). In four patients the plasma concentrations of morphine after colostomy administration were lower at all times than after rectal administration, and in three only small amounts of morphine were detectable. One patient showed higher plasma concentrations after colostomy application than after rectal administration. It is concluded that administration of morphine suppositories in a colostomy cannot be recommended. © 1990 Springer-Verlag.
引用
收藏
页码:49 / 50
页数:2
相关论文
共 6 条
[1]  
ELLISON NM, 1984, CLIN PHARMACY, V3, P614
[2]   THE BIOAVAILABILITY OF RECTALLY ADMINISTERED MORPHINE [J].
JONSSON, T ;
CHRISTENSEN, CB ;
JORDENING, H ;
FROLUND, C .
PHARMACOLOGY & TOXICOLOGY, 1988, 62 (04) :203-205
[3]   DRASTIC IMPROVEMENT IN THE RECTAL ABSORPTION PROFILE OF MORPHINE IN MAN [J].
MOOLENAAR, F ;
YSKA, JP ;
VISSER, J ;
MEIJER, DKF .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 29 (01) :119-121
[4]   RECTAL ADMINISTRATION OF MORPHINE HYDROGEL - ABSORPTION AND BIOAVAILABILITY IN WOMEN [J].
WESTERLING, D ;
ANDERSSON, KE .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1984, 28 (05) :540-543
[5]   ABSORPTION AND BIOAVAILABILITY OF RECTALLY ADMINISTERED MORPHINE IN WOMEN [J].
WESTERLING, D ;
LINDAHL, S ;
ANDERSSON, KE ;
ANDERSSON, A .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1982, 23 (01) :59-64
[6]   INFLUENCE OF RENAL-FUNCTION ON THE ELIMINATION OF MORPHINE AND MORPHINE GLUCURONIDES [J].
WOLFF, J ;
BIGLER, D ;
CHRISTENSEN, CB ;
RASMUSSEN, SN ;
ANDERSEN, HB ;
TONNESEN, KH .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 34 (04) :353-357